Immunohistochemistry (IHC)
(Formalin-fixed, paraffin-embedded human Spleen stained with TRAcP Monoclonal Antibody (SPM601))
Mouse TRAcP (Tartrate-Resistant Acid Phosphatase) Monoclonal Antibody | anti-ACP5 antibody
TRAcP (Tartrate-Resistant Acid Phosphatase) (Hairy Cell Leukemia Marker) Mouse Monoclonal Antibody
Immunofluorescence (0.5-1ug/ml)
Immunohistochemistry (Formalin-fixed) (0.5-1ug/ml for 30 minutes at RT) (Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)
Immunohistochemistry (IHC)
(Formalin-fixed, paraffin-embedded human Spleen stained with TRAcP Monoclonal Antibody (SPM601))
Immunohistochemistry (IHC)
(Formalin-fixed, paraffin-embedded human Spleen stained with TRAcP Monoclonal Antibody (SPM601))
NCBI and Uniprot Product Information
NCBI Description
This gene encodes an iron containing glycoprotein which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. [provided by RefSeq, Aug 2008]
Uniprot Description
ACP5: Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias. Defects in ACP5 are the cause of spondyloenchondrodysplasia with immune dysregulation (SPENCDI). A disease characterized by vertebral and metaphyseal dysplasia, spasticity with cerebral calcifications, and strong predisposition to autoimmune diseases. The skeletal dysplasia is characterized by radiolucent and irregular spondylar and metaphyseal lesions that represent islands of chondroid tissue within bone. ACP5 inactivating mutations result in a functional excess of phosphorylated osteopontin causing deregulation of osteopontin signaling and consequential autoimmune disease. Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.
Protein type: Cofactor and Vitamin Metabolism - riboflavin; Motility/polarity/chemotaxis; EC 3.1.3.2; Phosphatase
Chromosomal Location of Human Ortholog: 19p13.2
Cellular Component: cytosol; integral to membrane
Molecular Function: acid phosphatase activity; ferric iron binding; ferrous iron binding
Biological Process: riboflavin metabolic process
Disease: Spondyloenchondrodysplasia With Immune Dysregulation
Research Articles on ACP5
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Product Notes
The ACP5 acp5 (Catalog #AAA439147) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The TRAcP (Tartrate-Resistant Acid Phosphatase) (Hairy Cell Leukemia Marker) Mouse Monoclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's TRAcP (Tartrate-Resistant Acid Phosphatase) can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin. Flow Cytometry (0.5-1ug/million cells in 0.1ml) Immunofluorescence (0.5-1ug/ml) Immunohistochemistry (Formalin-fixed) (0.5-1ug/ml for 30 minutes at RT) (Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes). Researchers should empirically determine the suitability of the ACP5 acp5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TRAcP (Tartrate-Resistant Acid Phosphatase), Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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