Western Blot (WB)
(Western blot analysis using Tip60 mouse mAb against truncated Tip60 recombinant protein.)
Mouse anti-Human TIP60 Monoclonal Antibody | anti-TIP60 antibody
Anti-TIP60 Mouse mAb
Western Blot (WB)
(Western blot analysis using Tip60 mouse mAb against truncated Tip60 recombinant protein.)
Western Blot (WB)
(Western blot analysis using Tip60 mouse mAb against truncated Tip60 recombinant protein.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded human liver carcinoma (A), recturn carcinoma (B), normal medulla tissue (C) and normal interbrain tissues (D), showing nuclear localization using Tip60 mouse mAb with DAB staining.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded human liver carcinoma (A), recturn carcinoma (B), normal medulla tissue (C) and normal interbrain tissues (D), showing nuclear localization using Tip60 mouse mAb with DAB staining.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Uniprot Description
Tip60: a histone acetyl transferase (HAT) of the MYST family. Originally isolated as an HIV-1 TAT-interactive protein. Plays an important role in regulating chromatin remodeling, transcription and other nuclear processes by acetylating nuclear proteins. Plays a role in DNA repair and apoptosis. Three splice variants have been described.
Protein type: Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator; Nucleolus
Chromosomal Location of Human Ortholog: 11q13.1
Cellular Component: NuA4 histone acetyltransferase complex; nucleolus; nucleoplasm; nucleus
Molecular Function: acetyltransferase activity; histone acetyltransferase activity; protein binding; transcription coactivator activity
Biological Process: DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; DNA double-strand break processing; DNA replication; DNA synthesis during DNA repair; double-strand break repair; double-strand break repair via nonhomologous end joining; histone acetylation; negative regulation of interleukin-2 production; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; proteasomal ubiquitin-dependent protein catabolic process; response to ionizing radiation; strand displacement
Research Articles on TIP60
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Product Notes
The TIP60 kat5 (Catalog #AAA475750) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-TIP60 Mouse mAb reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's TIP60 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the TIP60 kat5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TIP60, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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