Testing Data #1
(TIM-1 transfected NRK cells stained with Rat anti Mouse TIM-1 (MBS224461))
Rat TIM-1 Monoclonal Antibody | anti-TIM-1 antibody
RAT ANTI MOUSE TIM-1:RPE
Gene Names
Havcr1; Tim1; KIM-1; TIM-1; Timd1; AI503787
Applications
Flow Cytometry, Functional Assay
Synonyms
TIM-1; Monoclonal Antibody; RAT ANTI MOUSE TIM-1:RPE; anti-TIM-1 antibody
Host
Rat
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
RMT1-10
Form/Format
Purified IgG conjugated to R. Phycoerythrin (RPE) - lyophilised.
Sequence Length
282
Applicable Applications for anti-TIM-1 antibody
Flow cytometry (FC/FACS)
Application Notes
Flow Cytometry: Use 10ul of the suggested working dilution to label 1x106 cells in 100ul.
Flow Cytometry: Minimum Dilution: Neat
Flow Cytometry: Minimum Dilution: Neat
Reconstitution
Reconstitute with 1.0 ml distilled water. Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. MyBioSource recommends that the vial is gently mixed after reconstitution.
Perservative Stabilisers
Perservative Stabilisers
Immunogen
Full-length mouse Tim-1-Ig, containing both the IgV and mucin domains of Tim-1.
Fusion Partners
Fusion Partners
Target Species
Mouse
Preparation and Storage
Prior to reconstitution store at 4 degree C. After reconstitution store at 4 degree C. DO NOT FREEZE. This product should be stored undiluted. This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 12 months from date of reconstitution.
Shelf Life: 12 months from date of reconstitution.
Testing Data #1
(TIM-1 transfected NRK cells stained with Rat anti Mouse TIM-1 (MBS224461))
Testing Data #1
(TIM-1 transfected NRK cells stained with Rat anti Mouse TIM-1 (MBS224461))
Testing Data #2
(TIM-1 transfected NRK cells stained with Rat anti Mouse TIM-1:FITC (MBS224498))
Testing Data #2
(TIM-1 transfected NRK cells stained with Rat anti Mouse TIM-1:FITC (MBS224498))
Related Product Information for anti-TIM-1 antibody
Rat anti Mouse TIM-1 antibody, clone MBS239187-10 recognizes mouse Tim-1 (T-cell immunoglobulin mucin 1), a cell surface glycoprotein and member of the immunoglobulin superfamily, which was first identified as the hepatitis A virus cellular receptor (HAVCR), and is highly expressed in the liver (isoform Tim-1a) and the kidneys (isoform Tim-1b). Tim-1 is highly expressed by activated CD4+ T cells, and acts as a positive/negative co-stimulatory molecule of T cell proliferation, cytokine production and tolerance abrogation, and is the receptor for Tim-4, expressed on APCs. Tim-1 expression is greater on Th2 than Th1 cells, and studies have shown that interaction between Tim-1 on Th2 cells and Tim-4 on dendritic cells (DCs), enhances Th2 cell function, and have implicated Tim-1 as a critical player in the development of atopic disease, and in particular airway hypersensitivity. Polymorphic forms of Tim-1 are associated with increased susceptibility to asthma, eczema and Rheumatoid arthritis. Rat anti Mouse TIM-1 antibody, clone MBS239187-10 has been shown to promote Th2 responses, and inhibit antigen-specific T cell proliferation, in contrast to the agonistic function of many Tim-1 antibodies (Xiao et al. 2007). Rat anti Mouse TIM-1 antibody, clone MBS239187-10 has been shown to reduce the severity of EAE (experimental autoimmune encephalomyelitis) and delay disease onset, in mice studies (Xiao et al. 2007).
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
30,925 Da
NCBI Official Full Name
hepatitis A virus cellular receptor 1 homolog isoform b
NCBI Official Synonym Full Names
hepatitis A virus cellular receptor 1
NCBI Official Symbol
Havcr1
NCBI Official Synonym Symbols
Tim1; KIM-1; TIM-1; Timd1; AI503787
NCBI Protein Information
hepatitis A virus cellular receptor 1 homolog; HAVcr-1; T-cell immunoglobulin and mucin domain containing 1; T-cell immunoglobulin mucin receptor 1; TIMD-1; kidney injury molecule 1; t cell immunoglobulin and mucin domain-containing protein 1; t cell membrane protein 1
UniProt Protein Name
Hepatitis A virus cellular receptor 1 homolog
Protein Family
UniProt Gene Name
Havcr1
UniProt Synonym Gene Names
Kim1; Tim1; Timd1; HAVcr-1; KIM-1; TIMD-1; TIM-1
UniProt Entry Name
HAVR1_MOUSE
Uniprot Description
TIM-1: May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4. In case of human hepatitis A virus (HHAV) infection, functions as a cell-surface receptor for the virus. May play a role in kidney injury and repair. Belongs to the immunoglobulin superfamily. TIM family.
Protein type: Membrane protein, integral
Cellular Component: membrane; integral to membrane
Molecular Function: protein binding
Biological Process: positive regulation of mast cell activation
Research Articles on TIM-1
Similar Products
Product Notes
The TIM-1 havcr1 (Catalog #AAA224567) is an Antibody produced from Rat and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's TIM-1 can be used in a range of immunoassay formats including, but not limited to, Flow cytometry (FC/FACS). Flow Cytometry: Use 10ul of the suggested working dilution to label 1x106 cells in 100ul. Flow Cytometry: Minimum Dilution: Neat. Researchers should empirically determine the suitability of the TIM-1 havcr1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TIM-1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
