Mouse Thyroglobulin Monoclonal Antibody | anti-TG antibody
Thyroglobulin (T3/T4) Monoclonal Antibody
ELISA Titer**: 1:102,400
(Note: * Determined by radial immunodiffusionfor several lots of ascites.
**ELISA is an indirect assay againstthyroglobulin on the solid phase. Titers represent endpoint dilutions that achieveabsorbance values >= 0.1.)
NCBI and Uniprot Product Information
NCBI Description
Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq]
Uniprot Description
TG: Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). Defects in TG are the cause of thyroid dyshormonogenesis 3 (TDH3). A disorder due to thyroid dyshormonogenesis, causing large goiters of elastic and soft consistency in the majority of patients. Although the degree of thyroid dysfunction varies considerably among patients with defective thyroglobulin synthesis, patients usually have a relatively high serum free triiodothyronine (T3) concentration with disproportionately low free tetraiodothyronine (T4) level. The maintenance of relatively high free T3 levels prevents profound tissue hypothyroidism except in brain and pituitary, which are dependent on T4 supply, resulting in neurologic and intellectual defects in some cases. Variations in TG are associated with susceptibility to autoimmune thyroid disease type 3 (AITD3). AITDs including Graves disease (GD) and Hashimoto thyroiditis (HT), are among the most common human autoimmune diseases. They are complex diseases, which are caused by an interaction between susceptibility genes and nongenetic factors, such as infection. Belongs to the type-B carboxylesterase/lipase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 8q24
Cellular Component: extracellular space; extracellular region
Molecular Function: hormone activity
Biological Process: regulation of myelination; iodide transport; thyroid gland development; hormone biosynthetic process; signal transduction; thyroid hormone metabolic process
Disease: Thyroid Dyshormonogenesis 3; Autoimmune Thyroid Disease, Susceptibility To, 3
Research Articles on TG
2. Case Report: Identification of a neck lump as a lymph node metastasis from an occult contralateral papillary microcarcinoma of the thyroid- key role of thyroglobulin assay in the fine-needle aspirate.
3. The population living in two areas was exposed to consequences of severe and moderate iodine deficiency
4. existence of four single nucleotide polymorphisms among Han Chinese, one SNP haplotype with Hashimoto thyroiditis suggests that TG may be a susceptibility gene
5. Results of our study suggest that thyroglobulin is an autoantigen that is recognized by thyroid MALT lymphoma cells.
6. the frequencies of genotypes in the TG gene E10, E12, and E33 SNPs were not found to be significantly different in Grave disease patients who developed GD when aged over 40 years when compared with those aged below 40 years
7. Elevated thyroglobulin levels post surgery are associated with disease recurrence in papillary thyroid carcinoma
8. analysis of family data did not show linkage of the thyroglobulin gene with autoimmune thyroid diseases nor did analysis of case-control data show association of Tgms2 or SNPs with Graves' disease
9. There is an association of the IVS30+G>T mutation of the thyroglobulin gene with hypothyroidism.
10. three single nucleotide polymorphisms were identified within the Tg gene
11. connection between infection of H. pylori and the occurrence of anti-TPO autoantibodies representing thyroid autoimmunity and gastric parietal cells autoantibodies representing the thyrogastric syndrome
12. analysis of the recurrence of the p.R277X/p.R1511X compound heterozygous mutation in the TG gene in two unrelated families (one Argentinian and another Brazilian) with congenital hypothyroidism, goiter and impairment of TG synthesis
13. peptides from autoantigens are also associated to HLA-DR in vivo and therefore may well be involved in the maintenance and the regulation of the autoimmune response
14. Tg and TgAb negativity at the time of ablation is not a predictive determinant for future recurrent status.
15. levels of thyroglobulin (Tg) mRNA in the TSH-stimulated lymphocytes were noticeably increased in subjects with thyroid disease suggesting an interesting relationship between production of Tg antigen in peripheral blood and autoimmunity in thyroid disease
16. Observational study of gene-disease association. (HuGE Navigator)
17. There is no systematic variation during the menstrual cycle in autoantibodies against thyroid peroxidase, thyroglobulin, and thyrotropin receptor
18. We have identified the thyroglobulin gene in females with autoimmune thyroid diseases.
19. expression level of thyroglobulin mRNA in the anaplastic thyroid carcinoma tissue and cell lines was <10(2) times higher than that in the differentiated thyroid carcinomas.
20. study showed Taiwanese patients with the C/C genotype of E33SNP, smoking, ophthalmopathy & positive TSH-receptor antibodies at the end of the treatment were more likely to have a relapse of Graves' hyperthyroidism after antithyroid medication is withdrawn
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Product Notes
The TG tg (Catalog #AAA190443) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Thyroglobulin can be used in a range of immunoassay formats including, but not limited to, Immunoassay. These antibodies may be used inimmunoassays to detect and quantitatethyroglobulin. Other applications areunder investigation. Researchers should empirically determine the suitability of the TG tg for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Thyroglobulin, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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