Mouse anti-Human Tenascin III-B Monoclonal Antibody | anti-ITGAM antibody

Tenascin III-B (MaxLight 650)

Gene Names

ITGAM; CR3A; MO1A; CD11B; MAC-1; MAC1A; SLEB6

Reactivity

Human

Applications

Immunohistochemistry, Western Blot

Purity

Purified by Protein A Affinity Chromatography.

Synonyms

Tenascin III-B; Monoclonal Antibody; Tenascin III-B (MaxLight 650); anti-ITGAM antibody

Ordering
Cat. Num. AAA6246602 When autocomplete results are available use up and down arrows to review and enter to select. Touch device users, explore by touch or with swipe gestures. For Research Use Only!

Host

Mouse

Reactivity

Human

Clonality

Monoclonal

Isotype

IgG1,k

Clone Number

2Q566

Specificity

Recognizes an epitope contained within domain B in the set of alternatively spliced repeats similar to fibronectin type III repeats, of human tenascin.

Purity/Purification

Purified by Protein A Affinity Chromatography.

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight650.

Applicable Applications for anti-ITGAM antibody

Immunohistochemistry (IHC), Western Blot (WB)

Immunogen

Human tenascin.

Conjugate

MaxLight650

Preparation and Storage

Store at 4 degree C. Do Not Freeze.

Product Categories/Family for anti-ITGAM antibody

Antibodies; Extracellular Matrix Proteins

References

FEBS (1993) 332:39-43.

NCBI and Uniprot Product Information

NCBI GI #

224831239

NCBI GeneID

3684

NCBI Accession #

NP_001139280.1

NCBI GenBank Nucleotide #

NM_001145808.1

UniProt Accession #

P11215; Q4VAK0; Q4VAK1; Q4VAK2

Molecular Weight

127,179 Da

NCBI Official Full Name

integrin alpha-M isoform 1

NCBI Official Synonym Full Names

integrin, alpha M (complement component 3 receptor 3 subunit)

NCBI Official Symbol

ITGAM

NCBI Official Synonym Symbols

CR3A; MO1A; CD11B; MAC-1; MAC1A; SLEB6

NCBI Protein Information

integrin alpha-M; CR-3 alpha chain; antigen CD11b (p170); leukocyte adhesion receptor MO1; CD11 antigen-like family member B; macrophage antigen alpha polypeptide; cell surface glycoprotein MAC-1 subunit alpha; neutrophil adherence receptor alpha-M subuni

UniProt Protein Name

Integrin alpha-M

Protein Family

Integrin

UniProt Gene Name

ITGAM

UniProt Synonym Gene Names

CD11B; CR3A

UniProt Entry Name

ITAM_HUMAN

NCBI Description

This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Uniprot Description

ITGAM: a single-pass type I membrane protein of the integrin alpha chain family. Implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. Also known as CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the RGD peptide in C3b. A receptor for fibrinogen, factor X and ICAM1. Heterodimer of an alpha and a beta subunit. Alpha-M associates with beta-2. Predominantly expressed in monocytes and granulocytes.

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: cell surface; plasma membrane; integrin complex; nucleus; external side of plasma membrane

Molecular Function: heparan sulfate proteoglycan binding; heparin binding; protein binding; opsonin binding; protein heterodimerization activity; metal ion binding; glycoprotein binding

Biological Process: integrin-mediated signaling pathway; neutrophil chemotaxis; extracellular matrix organization and biogenesis; microglia development; activated T cell proliferation; leukocyte migration during inflammatory response; cellular extravasation; toll-like receptor signaling pathway; innate immune response; cell adhesion; blood coagulation; toll-like receptor 4 signaling pathway; leukocyte migration

Disease: Systemic Lupus Erythematosus, Susceptibility To, 6

Research Articles on ITGAM

1. Complement receptor 3 (CR3) inhibition impairs phagocytosis of serum-opsonized zymosan but has little impact on phagocytosis of unopsonized zymosan in the absence or presence of lipopolysaccharide.

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Product Notes

The ITGAM itgam (Catalog #AAA6246602) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Tenascin III-B (MaxLight 650) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Tenascin III-B can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), Western Blot (WB). Researchers should empirically determine the suitability of the ITGAM itgam for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Tenascin III-B, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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