Mouse anti-Human TBX5 Monoclonal Antibody | anti-TBX5 antibody

Anti-TBX5 Mouse mAb

Cat. Num. AAA475927

• Gene Names: TBX5; HOS
• Reactivity: Human
• Applications: Western Blot
• Synonyms: TBX5; Monoclonal Antibody; Anti-TBX5 Mouse mAb; HOS; anti-TBX5 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 7B11
• Form/Format: Ascitic fluid containing 0.03% sodium azide.
• Sequence Length: 468

• Applicable Applications for anti-TBX5 antibody: Western Blot (WB)
• Immunogen: Purified recombinant fragment of TBX5 expressed in E Coli.

Western Blot (WB)

(Western blot analysis using TBX5 mouse mAb against HepG2 cell lysate (1).)

Related Product Information for anti-TBX5 antibody

Entrez Summary: TBX5, also known as T-box 5. It is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. It is closely linked to related family member T-box 3 (ulnar mammary syndrome) on human chromosome 12. The TBX5 protein may play a role in heart development and specification of limb identity. Mutations in this gene have been associated with Holt-Oram syndrome, a developmental disorder affecting the heart and upper limbs. Several transcript variants encoding different isoforms have been described for this gene.

NCBI and Uniprot Product Information

• NCBI GI #: 18201894
• NCBI GeneID: 6910
• NCBI Accession #: NP_542448.1
• NCBI GenBank Nucleotide #: NM_080717.2
• UniProt Accession #: Q99593; O15301; Q96TB0; Q9Y4I2; A6ND77
• Molecular Weight: 53
• NCBI Official Full Name: T-box transcription factor TBX5 isoform 3
• NCBI Official Synonym Full Names: T-box 5
• NCBI Official Symbol: TBX5
• NCBI Official Synonym Symbols: HOS
• NCBI Protein Information: T-box transcription factor TBX5
• UniProt Protein Name: T-box transcription factor TBX5
• Protein Family: T-box transcription factor
• UniProt Gene Name: TBX5
• UniProt Synonym Gene Names: T-box protein 5

NCBI Description

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is closely linked to related family member T-box 3 (ulnar mammary syndrome) on human chromosome 12. The encoded protein may play a role in heart development and specification of limb identity. Mutations in this gene have been associated with Holt-Oram syndrome, a developmental disorder affecting the heart and upper limbs. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

TBX5: Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation. Defects in TBX5 are the cause of Holt-Oram syndrome (HOS). HOS is a developmental disorder affecting the heart and upper limbs. It is characterized by thumb anomaly and atrial septal defects. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 12q24.21

Cellular Component: cytoplasm; nucleoplasm; nucleus

Molecular Function: DNA binding; protein binding; sequence-specific DNA binding; transcription factor activity; transcription factor binding

Biological Process: cell-cell signaling; embryonic forelimb morphogenesis; embryonic limb morphogenesis; forelimb morphogenesis; heart development; negative regulation of cardiac muscle cell proliferation; negative regulation of cell migration; negative regulation of cell proliferation; pericardium development; positive regulation of cardioblast differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; transcription initiation from RNA polymerase II promoter

Disease: Holt-oram Syndrome