Mouse TAL1 Monoclonal Antibody | anti-TAL1 antibody

TAL1 antibody

Cat. Num. AAA833915

• Gene Names: TAL1; SCL; TCL5; tal-1; bHLHa17
• Applications: Flow Cytometry, Functional Assay, Immunofluorescence, Western Blot
• Purity: TAL1 antibody was purified by affinity chromatography.
• Synonyms: TAL1; Monoclonal Antibody; TAL1 antibody; Monoclonal TAL1; Anti-TAL1; T-cell acute lymphocytic leukemia 1; SCL; bHLHa17; TCL5; Class A basic helix-loop-helix protein 17; Stem cell protein; T-cell leukemia/lymphoma protein 5; BHLHA17; TAL 1; TAL-1; anti-TAL1 antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 5C4
• Purity/Purification: TAL1 antibody was purified by affinity chromatography.
• Form/Format: Supplied in PBS buffer, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide.
• Concentration: 500 ug-1 mg/ml (varies by lot)
• Sequence Length: 331

• Applicable Applications for anti-TAL1 antibody: Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB)
• Application Notes: FC: 1:100; IF: 1:100; WB: 1:2000
• Biological Significance: Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation.
• Cross-Reactivity: Human
• Immunogen: TAL1 antibody was raised in mouse using a full length recombinant protein of human TAL1 (NP_003180) produced in HEK293T cells, as the immunogen.
• Preparation and Storage: Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Flow Cytometry (FC/FACS)

(Flow Cytometric analysis of HEK293T cells transfected with either recombinant TAL1 protein (red) or empty vector (blue) stained using TAL1 antibody)

Western Blot (WB)

(Western Blot analysis of HEK293T cell lysates (5 ug) transfected with either recombinant TAL1 protein (Right) or empty vector (Left) detected with TAL1 antibody)

Immunofluorescence (IF)

(Immunofluorescent staining of COS7 cells transiently transfected with recombinant TAL1 protein using TAL1 antibody)

Related Product Information for anti-TAL1 antibody

Mouse monoclonal TAL1 antibody

Product Categories/Family for anti-TAL1 antibody

Cancer

NCBI and Uniprot Product Information

• NCBI GI #: 4507363
• NCBI GeneID: 6886
• NCBI Accession #: NP_003180
• NCBI GenBank Nucleotide #: NM_003189.2
• UniProt Accession #: P17542; D3DQ24
• Molecular Weight: 16,548 Da
• NCBI Official Full Name: T-cell acute lymphocytic leukemia protein 1 isoform 1
• NCBI Official Synonym Full Names: T-cell acute lymphocytic leukemia 1
• NCBI Official Symbol: TAL1
• NCBI Official Synonym Symbols: SCL; TCL5; tal-1; bHLHa17
• NCBI Protein Information: T-cell acute lymphocytic leukemia protein 1
• UniProt Protein Name: T-cell acute lymphocytic leukemia protein 1
• Protein Family: Transaldolase
• UniProt Gene Name: TAL1
• UniProt Synonym Gene Names: BHLHA17; SCL; TCL5; TAL-1; bHLHa17
• UniProt Entry Name: TAL1_HUMAN

Uniprot Description

TAL1: a basic helix-loop-helix transcription. Regulates differentiation and survival during hemopoiesis. Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of eryhtroid differentiation. Mutations are associated with T-cell leukemia and melanoma. Binds to the LIM domain containing protein Rhombotin-2.

Protein type: Oncoprotein; DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 1p32

Cellular Component: transcription factor complex; histone deacetylase complex; nuclear chromatin; nucleus

Molecular Function: protein binding; enzyme binding; protein heterodimerization activity; histone deacetylase binding; chromatin binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; cell fate commitment; positive regulation of chromatin assembly or disassembly; erythrocyte maturation; embryonic hemopoiesis; megakaryocyte differentiation; astrocyte fate commitment; positive regulation of erythrocyte differentiation; positive regulation of transcription, DNA-dependent; locomotory behavior; negative regulation of transcription from RNA polymerase II promoter; positive regulation of mitotic cell cycle; regulation of cell proliferation; regulation of transcription from RNA polymerase II promoter; positive regulation of protein complex assembly; positive regulation of cell division; spinal cord association neuron differentiation; erythrocyte differentiation; positive regulation of transcription from RNA polymerase II promoter; hemopoiesis; platelet formation; angiogenesis; basophil differentiation

Disease: Leukemia, Acute Lymphoblastic