Mouse STAT4 Monoclonal Antibody | anti-STAT4 antibody

Mouse monoclonal STAT4 antibody

Cat. Num. AAA5307410

• Gene Names: STAT4; SLEB11
• Applications: Immunohistochemistry, Western Blot
• Purity: Purified by affinity chromatography.
• Synonyms: STAT4; Monoclonal Antibody; Mouse monoclonal STAT4 antibody; STAT4 antibody; anti-STAT4 antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 2A2
• Purity/Purification: Purified by affinity chromatography.
• Form/Format: Supplied in PBS buffer, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide.
• Concentration: 500 ug-1 mg/ml (varies by lot)
• Sequence Length: 748

• Applicable Applications for anti-STAT4 antibody: Immunohistochemistry (IHC), Western Blot (WB)
• Application Notes: IHC: 1:50; WB: 1:100
• Immunogen: STAT4 antibody was raised in mouse using a recombinant fragment expressed in E Coli corresponding to amino acids 633-652 of human Stat4 as the immunogen.
• Cross-Reactivity: Human
• Preparation and Storage: Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemical analysis of STAT4 protein in paraffin embedded Carcinoma of Human lung tissue using STAT4 antibody)

Product Categories/Family for anti-STAT4 antibody

DNA & RNA

NCBI and Uniprot Product Information

• NCBI GI #: 345110660
• NCBI GeneID: 6775
• NCBI Accession #: NP_001230764.1
• NCBI GenBank Nucleotide #: NM_001243835.1
• UniProt Accession #: Q14765; Q96NZ6
• Molecular Weight: 85,941 Da
• NCBI Official Full Name: signal transducer and activator of transcription 4
• NCBI Official Synonym Full Names: signal transducer and activator of transcription 4
• NCBI Official Symbol: STAT4
• NCBI Official Synonym Symbols: SLEB11
• NCBI Protein Information: signal transducer and activator of transcription 4
• UniProt Protein Name: Signal transducer and activator of transcription 4
• Protein Family: Signal transducer and activator of transcription
• UniProt Gene Name: STAT4

NCBI Description

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011]

Uniprot Description

STAT4: transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of many cytokines and growth-factor receptors. Essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 2q32.2-q32.3

Cellular Component: nucleoplasm

Molecular Function: protein binding

Biological Process: JAK-STAT cascade

Disease: Systemic Lupus Erythematosus, Susceptibility To, 11