Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Human Breast Carcinoma Tissue using Smad3 Mouse mAb diluted at 1:200.)
Mouse anti-Human Smad3 Monoclonal Antibody | anti-Smad3 antibody
Smad3 Mouse Monoclonal Antibody(1E8)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Human Breast Carcinoma Tissue using Smad3 Mouse mAb diluted at 1:200.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Human Breast Carcinoma Tissue using Smad3 Mouse mAb diluted at 1:200.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis. [provided by RefSeq, Apr 2009]
Uniprot Description
SMAD3: transcription factor phosphorylated and activated by TGF-beta-type receptors. A receptor-regulated Smad (R-smad). Binds directly to consensus DNA-binding elements in the promoters of target genes. In mouse required for establishemnt of the mucosal immune response and proper development of skeleton.
Protein type: DNA-binding; Nuclear receptor co-regulator; Transcription factor
Chromosomal Location of Human Ortholog: 15q22.33
Cellular Component: cytoplasm; cytosol; nuclear chromatin; nuclear inner membrane; nucleoplasm; nucleus; receptor complex; transcription factor complex
Molecular Function: bHLH transcription factor binding; identical protein binding; phosphatase binding; protein binding; protein homodimerization activity; protein kinase binding; sequence-specific DNA binding; transcription factor activity; transcription factor binding; transforming growth factor beta receptor binding; transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity; ubiquitin binding; ubiquitin protein ligase binding; zinc ion binding
Biological Process: activin receptor signaling pathway; caspase activation; cell cycle arrest; evasion of host defenses by virus; immune response; intercellular junction assembly and maintenance; negative regulation of cell growth; negative regulation of fat cell differentiation; negative regulation of mitotic cell cycle; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of nitric oxide biosynthetic process; positive regulation of transcription factor import into nucleus; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; primary microRNA processing; reduction of cytosolic calcium ion concentration; regulation of transcription from RNA polymerase II promoter; regulation of transforming growth factor beta receptor signaling pathway; regulation of transforming growth factor-beta2 production; response to hypoxia; SMAD protein complex assembly; transforming growth factor beta receptor signaling pathway; transport; wound healing
Disease: Loeys-dietz Syndrome 3
Research Articles on Smad3
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Product Notes
The Smad3 smad3 (Catalog #AAA9417574) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Smad3 Mouse Monoclonal Antibody(1E8) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Smad3 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC). Immunohistochemistry: 1:100-1:200. Researchers should empirically determine the suitability of the Smad3 smad3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Smad3, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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