Western Blot (WB)
(Western Blot detection against Immunogen (33.7kD).)
Mouse anti-Human SLC6A20 Monoclonal Antibody | anti-SLC6A20 antibody
SLC6A20 (Solute Carrier Family 6 Member 20, Sodium- and Chloride-dependent Transporter XTRP3, Sodium/imino-acid Transporter 1, SIT1, Transporter rB21A Homolog, XT3, XTRP3)
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Dilution: ELISA: 0.1ng/ml
Western Blot (WB)
(Western Blot detection against Immunogen (33.7kD).)
Western Blot (WB)
(Western Blot detection against Immunogen (33.7kD).)
Testing Data
(Detection limit for recombinant GST tagged SLC6A20 is ~0.1ng/ml as a capture antibody.)
Testing Data
(Detection limit for recombinant GST tagged SLC6A20 is ~0.1ng/ml as a capture antibody.)
NCBI and Uniprot Product Information
NCBI Description
Transport of small hydrophilic substances across cell membranes is mediated by substrate-specific transporter proteins which have been classified into several families of related genes. The protein encoded by this gene is a member of the subgroup of transporter with unidentified substrates within the Na+ and Cl- coupled transporter family. This gene is expressed in kidney, and its alternative splicing generates 2 transcript variants. [provided by RefSeq, Jul 2008]
Uniprot Description
SLC6A20: Mediates the calcium-dependent uptake of imino acids such as L-proline, N-methyl-L-proline and pipecolate as well as N- methylated amino acids. Involved in the transport of glycine. Defects in SLC6A20 are a cause of hyperglycinuria (HG). It is a condition characterized by excess of glycine in the urine. In some cases it is associated with renal colic and renal oxalate stones. Defects in SLC6A20 are a cause of iminoglycinuria (IG). It is a disorder of renal tubular reabsorption of glycine and imino acids (proline and hydroxyproline), marked by excessive levels of all three substances in the urine. Haploinsufficiency of SLC6A20 combined with deficiency of the neutral amino acid transporter SLC6A19 or partially inactivating mutations in SLC36A2, is responsible for iminoglycinuria. Additional polymorphisms and mutations in SLC6A18 can contribute to the IG phenotype in some families. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A20 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transporter; Transporter, SLC family; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 3p21.3
Cellular Component: integral to plasma membrane; apical plasma membrane; plasma membrane
Molecular Function: neurotransmitter:sodium symporter activity; amino acid transmembrane transporter activity
Biological Process: glycine transport; neurotransmitter transport; amino acid transport; ion transport; proline transport; transmembrane transport
Disease: Iminoglycinuria; Hyperglycinuria
Research Articles on SLC6A20
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Product Notes
The SLC6A20 slc6a20 (Catalog #AAA6010238) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The SLC6A20 (Solute Carrier Family 6 Member 20, Sodium- and Chloride-dependent Transporter XTRP3, Sodium/imino-acid Transporter 1, SIT1, Transporter rB21A Homolog, XT3, XTRP3) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SLC6A20 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Suitable for use in ELISA and Western Blot. Dilution: ELISA: 0.1ng/ml. Researchers should empirically determine the suitability of the SLC6A20 slc6a20 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: KATFNYENCL KKVSLLLTNT FDLEDGFLTA SNLEQVKGYL ASAYPSKYSE MFPQIKNCSL ESELDTAVQ. It is sometimes possible for the material contained within the vial of "SLC6A20, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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