Mouse anti-Human Serum Amyloid P Monoclonal Antibody | anti-APCS antibody

Serum Amyloid P, Human (SAP, APCS, PTX2, mature chain 204aa, chromosome 1q21-23)

Cat. Num. AAA631703

• Gene Names: APCS; SAP; PTX2; MGC88159
• Reactivity: Human
• Applications: ELISA
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: Serum Amyloid P; Monoclonal Antibody; Human (SAP; APCS; PTX2; mature chain 204aa; chromosome 1q21-23); Anti -Serum Amyloid P; anti-APCS antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 2Q2174
• Specificity: Recognizes human serum amyloid P (SAP).
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, 10mM sodium azide.

• Applicable Applications for anti-APCS antibody: ELISA (EL/EIA)
• Application Notes: Suitable for use in ELISA.
• Immunogen: Human serum amyloid P
• Hybridoma: NS1 myeloma cell line
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-APCS antibody

Amyloid consists mainly of rigid, non-branching protein fibrils, together with rod-like aggregates of a pentagonal-shaped glycoprotein called amyloid P protein. Amyloid P protein, also known as component P, comprises 10% of amyloid tissue. It is present in all but the central nervous system forms of amyloid. Amyloid P protein is a constituent of normal basement membranes and the microfibrillary elastic fiber network.

Product Categories/Family for anti-APCS antibody

Antibodies; Abs to Amyloid

NCBI and Uniprot Product Information

• NCBI GI #: 220068
• NCBI GeneID: 325
• UniProt Accession #: P02743
• Molecular Weight: 25,387 Da
• NCBI Official Full Name: serum amyloid P component
• NCBI Official Synonym Full Names: amyloid P component, serum
• NCBI Official Symbol: APCS
• NCBI Official Synonym Symbols: SAP; PTX2; MGC88159
• NCBI Protein Information: serum amyloid P-component; pentaxin-related; OTTHUMP00000024355; 9.5S alpha-1-glycoprotein
• UniProt Protein Name: Serum amyloid P-component
• Protein Family: Serum amyloid P-component
• UniProt Gene Name: APCS
• UniProt Synonym Gene Names: PTX2
• UniProt Entry Name: SAMP_HUMAN

NCBI Description

The protein encoded by this gene is a glycoprotein, belonging to the pentraxin family of proteins, which has a characteristic pentameric organization. These family members have considerable sequence homology which is thought to be the result of gene duplication. The binding of the encoded protein to proteins in the pathological amyloid cross-beta fold suggests its possible role as a chaperone. This protein is also thought to control the degradation of chromatin. It has been demonstrated that this protein binds to apoptotic cells at an early stage, which raises the possibility that it is involved in dealing with apoptotic cells in vivo. [provided by RefSeq]

Uniprot Description

APCS: Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin. SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits. Belongs to the pentaxin family.

Protein type: Secreted, signal peptide; Chaperone; Secreted

Chromosomal Location of Human Ortholog: 1q21-q23

Cellular Component: extracellular matrix; extracellular space; protein complex; extracellular region; nucleus

Molecular Function: complement component C1q binding; unfolded protein binding; virion binding; calcium ion binding; carbohydrate binding

Biological Process: protein folding; negative regulation of virion penetration into host cell; acute-phase response; negative regulation of acute inflammatory response; innate immune response; chaperone-mediated protein complex assembly; negative regulation of monocyte differentiation; negative regulation of viral reproduction