Mouse Serpin Peptidase Inhibitor Monoclonal Antibody | anti-SERPINB5 antibody
Mouse Anti Human Serpin Peptidase Inhibitor, Clade B Member 5
Gene Names
SERPINB5; PI5; maspin
Applications
ELISA, Western Blot, Immunofluorescence
Purity
SERPINB5 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Synonyms
Serpin Peptidase Inhibitor; Monoclonal Antibody; Mouse Anti Human Serpin Peptidase Inhibitor; Clade B Member 5; SERPINB5 Antibody; Serpin Peptidase Inhibitor Clade B Member 5; Mouse Anti Human; PI5; maspin; SERPINB5; serpin peptidase inhibitor clade B (ovalbumin) member 5; Serpin B5; Protease inhibitor 5; anti-SERPINB5 antibody
Host
Mouse
Clonality
Monoclonal
Isotype
IgG2b heavy chain and kappa light chain
Clone Number
PAT2N6AT
Purity/Purification
SERPINB5 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Form/Format
1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide.
Sequence Length
375
Applicable Applications for anti-SERPINB5 antibody
ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)
Application Notes
SERPINB5 antibody has been tested by ELISA, Western blot analysis and Immunofluorescence analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:1000 ~ 2000. Recommended starting dilution is 1:1000.
Immunogen
Anti-human SERPINB5 mAb is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human SERPINB5 amino acids 1-375 purified from E Coli.
Preparation and Storage
For periods up to 1 month store at 4 degree C, for longer periods of time, store at -20 degree C. Prevent freeze thaw cycles.
12 months at -20 degree C. 1 month at 4 degree C.
12 months at -20 degree C. 1 month at 4 degree C.
Related Product Information for anti-SERPINB5 antibody
Introduction: SERPINB5 (Maspin) is a tumor suppressor protein of the serine proteinase inhibitor family. Maspin plays a vital role in embryonic development through critical functions in cell adhesion. In addition, Maspin is present in normal breast and prostatic epithelial cells although down regulated in the particular carcinomas. SERPINB5 impedes the growth, invasion, and metastatic properties of mammary tumors as well as the invasive ability of pancreatic ductal adenocarcinoma cells. SERPINB5 being a breast tumor suppressor gene is a significant marker of the disease progression in breast neoplasms. Furthermore, high expression of maspin is linked to squamous cell carcinoma in non-small-cell lung cancer. Moreover, maspin expression has been directly linked with the biological aggressiveness of ovarian carcinoma. Maspin exhibits no serine protease inhibitory activity since it does not undergo the stressed to relaxed conformational transition typical of active serpins.
Product Categories/Family for anti-SERPINB5 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
25,763 Da
NCBI Official Full Name
serpin B5
NCBI Official Synonym Full Names
serpin peptidase inhibitor, clade B (ovalbumin), member 5
NCBI Official Symbol
SERPINB5
NCBI Official Synonym Symbols
PI5; maspin
NCBI Protein Information
serpin B5; PI-5; peptidase inhibitor 5; protease inhibitor 5 (maspin); serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5
UniProt Protein Name
Serpin B5
Protein Family
UniProt Gene Name
SERPINB5
UniProt Synonym Gene Names
PI5; PI-5
UniProt Entry Name
SPB5_HUMAN
Uniprot Description
maspin: Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. Interacts with IRF6. Normal mammary epithelial cells. Belongs to the serpin family. Ov-serpin subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 18q21.33
Cellular Component: extracellular space; cytoplasm
Molecular Function: serine-type endopeptidase inhibitor activity; protein binding
Biological Process: extracellular matrix organization and biogenesis; morphogenesis of an epithelium; cell motility; regulation of epithelial cell proliferation
Research Articles on SERPINB5
Similar Products
Product Notes
The SERPINB5 serpinb5 (Catalog #AAA140314) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Serpin Peptidase Inhibitor can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunofluorescence (IF). SERPINB5 antibody has been tested by ELISA, Western blot analysis and Immunofluorescence analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:1000 ~ 2000. Recommended starting dilution is 1:1000. Researchers should empirically determine the suitability of the SERPINB5 serpinb5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Serpin Peptidase Inhibitor, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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