Immunohistochemistry (IHC)
(Anti-SARM1 / SARM antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.)
Mouse anti-Human SARM1 / SARM Monoclonal Antibody | anti-SARM1 antibody
Mouse Monoclonal [clone Sarmy-1] (IgG2b) to Human SARM1 / SARM
Gene Names
SARM1; SARM; SAMD2; MyD88-5
Reactivity
Human
Applications
Immunohistochemistry, Immunoprecipitation
Purity
Purified
Synonyms
SARM1 / SARM; Monoclonal Antibody; Mouse Monoclonal [clone Sarmy-1] (IgG2b) to Human SARM1 / SARM; Anti-SARM1 / SARM Antibody (clone Sarmy-1) IHC-plus; SARM1; Tir-1 homolog; SARM; KIAA0524; SAMD2; Human SARM1; anti-SARM1 antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG2b
Clone Number
Sarmy-1
Specificity
Recognizes human SARM.
Purity/Purification
Purified
Form/Format
PBS, 10% glycerol, 0.02% sodium azide.
Concentration
1 mg/ml (varies by lot)
Sequence Length
724
Applicable Applications for anti-SARM1 antibody
Immunohistochemistry (IHC - Paraffin), Immunoprecipitation (IP)
Application Notes
IHC-P (10 ug/ml), IP (1:200)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibo...
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibo...
Target Species
Human
Immunogen Description
Recombinant human SARM (aa 93-292).
Immunogen Type
Recombinant protein
Immunogen
SARM1 / SARM antibody was raised against recombinant human SARM (aa 93-292).
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Immunohistochemistry (IHC)
(Anti-SARM1 / SARM antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.)
Immunohistochemistry (IHC)
(Anti-SARM1 / SARM antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.)
Related Product Information for anti-SARM1 antibody
Toll-like receptors (TLRs) play an essential role in the detection and elimination of invading microbes. They are type-1 transmembrane receptors, containing extracellular leucine rich repeats and an intracellular Toll/interleukin-1 receptor (TIR) domain. Upon stimulation, these receptors interact with specific TIR domain-containing adaptor proteins.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
75,337 Da
NCBI Official Full Name
sterile alpha and TIR motif-containing protein 1
NCBI Official Synonym Full Names
sterile alpha and TIR motif containing 1
NCBI Official Symbol
SARM1
NCBI Official Synonym Symbols
SARM; SAMD2; MyD88-5
NCBI Protein Information
sterile alpha and TIR motif-containing protein 1; tir-1 homolog; SAM domain-containing protein 2; sterile alpha and Armadillo repeat protein; sterile alpha motif domain-containing protein 2; sterile alpha and HEAT/Armadillo motif protein, ortholog of Drosophila
UniProt Protein Name
Sterile alpha and TIR motif-containing protein 1
Protein Family
UniProt Gene Name
SARM1
UniProt Synonym Gene Names
KIAA0524; SAMD2; SARM; MyD88-5; SAM domain-containing protein 2
UniProt Entry Name
SARM1_HUMAN
Uniprot Description
SARM1: Involved in innate immnune response. Acts as a negative regulator of TICAM1/TRIF-dependent Toll-like receptor signaling by inhibiting induction of TLR3- and TLR4-dependent genes. Specifically blocks TICAM1/TRIF-dependent transcription-factor activation and gene induction, without affecting the MYD88- dependent pathway or non-TLR signaling. Negative regulator of NF- kappa-B and IRF activation. 2 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 17q11
Cellular Component: microtubule; mitochondrion; axon; dendrite; cytoplasm; extrinsic to mitochondrial outer membrane; synapse; cytosol; cell junction
Biological Process: regulation of apoptosis; MyD88-independent toll-like receptor signaling pathway; regulation of dendrite morphogenesis; response to glucose stimulus; toll-like receptor signaling pathway; innate immune response; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway
Research Articles on SARM1
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Product Notes
The SARM1 sarm1 (Catalog #AAA245876) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Mouse Monoclonal [clone Sarmy-1] (IgG2b) to Human SARM1 / SARM reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SARM1 / SARM can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC - Paraffin), Immunoprecipitation (IP). IHC-P (10 ug/ml), IP (1:200) Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibo.. Researchers should empirically determine the suitability of the SARM1 sarm1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SARM1 / SARM, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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