Mouse anti-Human S100A10 Monoclonal Antibody | anti-S100A10 antibody

Anti-S100A10 Antibody, Mouse Monoclonal

Cat. Num. AAA8104949

• Gene Names: S100A10; 42C; P11; p10; GP11; ANX2L; CAL1L; CLP11; Ca[1]; ANX2LG
• Reactivity: Human
• Applications: Immunohistochemistry, Flow Cytometry, Functional Assay, Immunocytochemistry, Immunofluorescence
• Purity: Protein A
• Synonyms: S100A10; Monoclonal Antibody; Anti-S100A10 Antibody; Mouse Monoclonal; S100A10 Antibody; Mouse MAb; S100 calcium binding protein A10; Anti-42C Antibody; Anti-ANX2L Antibody; Anti-ANX2LG Antibody; Anti-CAL1L Antibody; Anti-Ca[1] Antibody; Anti-CLP11 Antibody; Anti-GP11 Antibody; Anti-MGC111133 Antibody; Anti-p10 Antibody; Anti-P11 Antibody; anti-S100A10 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: Mouse IgG1
• Clone Number: 03
• Specificity: Human S100A10
• Purity/Purification: Protein A
• Form/Format: Liquid; 0.2um filtered solution in PBS

• Applicable Applications for anti-S100A10 antibody: Immunohistochemistry-Paraffin (IHC-P), Flow Cytometry (FC/FACS/FCM), Immunocytochemistry (ICC), Immunofluorescence (IF)
• Application Notes: IHC-P: 1:50-1:200; ICC/IF: 1:20-1:100; FC/FACS/FCM: 1:25-1:100
• Immunogen: Recombinant Human S100A10 protein
• Conjugation: Unconjugated
• Preparation: This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human S100A10 (rh S100A10). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-S100A10 antibody

S100 protein is a family of low molecular weight protein found in vertebrates characterized by two EF-hand calcium-binding motifs. There are at least 21 different S100 proteins, and the name is derived from the fact that the protein is 100% soluble in ammonium sulfate at neutral pH. Most S100 proteins are disulfide-linked homodimer, and is normally present in cells derived from the neural crest, chondrocytes, macrophages, dendritic cells, etc. S1 proteins have been implicated in a variety of intracellular and extracellular functions. They are involved in regulation of protein phosphorylation, transcription factors, the dynamics of cytoskeleton constituents, enzyme activities, cell growth and differentiation, and the inflammatory response. Protein S100-A10, also known as Calpactin I light chain, Cellular ligand of annexin II, S100 calcium-binding protein A10, p10 protein, p11, ANX2LG and S100A10, is a member of the S100 family of small, dimeric EF hand-type Ca(2+)-binding proteins that generally modulate cellular target proteins in response to intracellular Ca(2+) signals. In contrast to all other S100 proteins, S100A10 is Ca(2+) insensitive because of amino acid replacements in its Ca(2+)-binding loops that lock the protein in a permanently active state. S100A10 forms a heterotetramer with annexin IIH and promotes carcinoma invasion and metastasis by plasminogen activation. S100A10 and annexin II contribute to the aggressive characteristics of anaplastic carcinoma, while playing a constitutive role in papillary carcinoma. S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target of tyrosine-specific kinase. S100A10 functions as a linker tethering certain transmembrane proteins to annexin A2 thereby assisting their traffic to the plasma membrane and/or their firm anchorage at certain membrane sites.

Product Categories/Family for anti-S100A10 antibody

Calcium-binding Proteins and Related Molecules

References

Gebhardt, C. et al., 2006, Biochem Pharmacol. 72 (11):1622-31. Ito, Y. et al., 2007, Anticancer Res. 27 (4C):2679-83. Svenningsson, P. et al., 2007, Curr Opin Pharmacol 7 (1):27-32. Rescher, U. et al., 2008, Pflugers Arch. 455 (4):575-82. Nonaka, D. et al., 2008, J. Cutan. Pathol. 35 (11): 1014-9. Lim, SY. et al., 2008, J Immunol. 181 (8): 5627-36. Heibeck TH. et al., 2009, J. Proteome Res. 8:3852-61.

NCBI and Uniprot Product Information

• NCBI GI #: 4506761
• NCBI GeneID: 6281
• NCBI Accession #: NP_002957.1
• NCBI GenBank Nucleotide #: NM_002966.2
• UniProt Accession #: P60903; P08206; Q5T1C5; A8K4V8
• Molecular Weight: 11,203 Da
• NCBI Official Full Name: protein S100-A10
• NCBI Official Synonym Full Names: S100 calcium binding protein A10
• NCBI Official Symbol: S100A10
• NCBI Official Synonym Symbols: 42C; P11; p10; GP11; ANX2L; CAL1L; CLP11; Ca[1]; ANX2LG
• NCBI Protein Information: protein S100-A10; S100 calcium binding protein A10 (annexin II ligand, calpactin I, light polypeptide (p11)); S100 calcium-binding protein A10 (annexin II ligand, calpactin I, light polypeptide (p11)); annexin II tetramer (AIIt) p11 subunit; calpactin I l
• UniProt Protein Name: Protein S100-A10
• Protein Family: Protein
• UniProt Gene Name: S100A10
• UniProt Synonym Gene Names: ANX2LG; CAL1L; CLP11
• UniProt Entry Name: S10AA_HUMAN

NCBI Description

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in exocytosis and endocytosis. [provided by RefSeq, Jul 2008]

Uniprot Description

S100A10: Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine- specific kinase. Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with SCN10A. Belongs to the S-100 family.

Protein type: Calcium-binding

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: extrinsic to plasma membrane; lipid raft

Molecular Function: protein binding; protein homodimerization activity; calcium ion binding; lipid binding

Biological Process: positive regulation of focal adhesion formation; positive regulation of stress fiber formation; protein heterotetramerization; positive regulation of binding; lipid raft formation; membrane budding