Mouse RSK2/3 Monoclonal Antibody | anti-RSK2/3 antibody

RSK2/3 antibody

• Gene Names: RPS6KA3; CLS; RSK; HU-3; RSK2; MRX19; ISPK-1; p90-RSK2; pp90RSK2; MAPKAPK1B; S6K-alpha3
• Applications: ELISA, Western Blot
• Purity: RSK2/3 antibody was purified by ammonium sulfate precipitation
• Synonyms: RSK2/3; Monoclonal Antibody; RSK2/3 antibody; Monoclonal RSK2/3; Anti-RSK2/3; RPS6KA3; ribosomal protein S6 kinase; 90kDa; polypeptide 3; 90 kDa ribosomal protein S6 kinase 3; BOS_26315; CLS; HU-3; insulin-stimulated protein kinase 1; ISPK-1; MAPK-activated protein kinase 1b; MAPKAPK-1b; MAPKAPK1B; MAPKAP kinase 1b; MAP kinase-activated protein kinase 1b; MPK-9; MRX19; NV16126; p90; p90-RSK2; p90RSK3; p90-RSK 3; pp90RSK2; protein kinase p90; rCG_36295; RGD1563860; ribosomal protein S6 kinase 2; Ribosomal protein S6 kinase alpha-3; ribosomal protein S6 kinase polypeptide 3; ribosomal S6 kinase 2; RP11-393H10.3; RP23-52L10.1; rsk; Rsk2; RSK-2; S6K-alpha3; S6K-alpha-3; S6KII; S6 kinase II; anti-RSK2/3 antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG2b kappa
• Clone Number: 3C1
• Purity/Purification: RSK2/3 antibody was purified by ammonium sulfate precipitation
• Form/Format: Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol
• Sequence Length: 740

• Applicable Applications for anti-RSK2/3 antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: WB: 1:1000-2000
• Biological Significance: The p90 ribosomal S6 kinases (RSKs) comprise a family of serine/threonine kinases that lie at the terminus of the ERK pathway. In humans, the RSK family consists of four isoforms (RSK1 to -4). RSK family members are unusual among serine/threonine kinases in that they contain two distinct kinase domains, both of which are catalytically functional. Theses kinase dimains are activated in a sequential manner by a series of phosphorylations. RSK regulates gene expression via association and phosphorylation of transcriptional regulators including c-Fos, estrogen receptor, NFkappaB/IkappaB alpha, cAMP-response element-binding protein (CREB).
• Cross-Reactivity: Human, Mouse, Rat
• Immunogen: RSK2/3 antibody was raised in Mouse using a recombinant human protein purified from E Coli(His/ABD-RSK3 415-733 a.a.) as the immunogen
• Preparation and Storage: Aliquot and store for 1 year at -20 degree C, avoid freeze/thaw cycles

Western Blot (WB)

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Related Product Information for anti-RSK2/3 antibody

Mouse monoclonal RSK2/3 antibody

Product Categories/Family for anti-RSK2/3 antibody

Signal Transduction

NCBI and Uniprot Product Information

• NCBI GI #: 4759050
• NCBI GeneID: 6197
• NCBI Accession #: NP_004577.1
• NCBI GenBank Nucleotide #: NM_004586.2
• Molecular Weight: 83,736 Da
• NCBI Official Full Name: ribosomal protein S6 kinase alpha-3
• NCBI Official Synonym Full Names: ribosomal protein S6 kinase, 90kDa, polypeptide 3
• NCBI Official Symbol: RPS6KA3
• NCBI Official Synonym Symbols: CLS; RSK; HU-3; RSK2; MRX19; ISPK-1; p90-RSK2; pp90RSK2; MAPKAPK1B; S6K-alpha3
• NCBI Protein Information: ribosomal protein S6 kinase alpha-3
• UniProt Protein Name: Ribosomal protein S6 kinase alpha-3
• UniProt Gene Name: RPS6KA3
• UniProt Synonym Gene Names: ISPK1; MAPKAPK1B; RSK2; S6K-alpha-3; p90-RSK 3; p90RSK3; ISPK-1; MAPK-activated protein kinase 1b; MAPKAP kinase 1b; MAPKAPK-1b; RSK-2
• UniProt Entry Name: KS6A3_HUMAN

NCBI Description

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS). [provided by RefSeq, Jul 2008]

Uniprot Description

RSK2: an AGC kinase of the RSK family. Phosphorylated and activated by Erk1 and -2 in response to many growth factors, polypeptide hormones and neurotransmitters. Several phosphorylation sites are important for its activation. Possesses two kinase domains connected by a regulator linker region. Phosphorylates a wide range of substrates including ribosomal protein S6. Prominently expressed in brain structures essential for cognitive function and learning.

Protein type: EC 2.7.11.1; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); AGC group; RSK family; RSK subfamily

Chromosomal Location of Human Ortholog: Xp22.2-p22.1

Cellular Component: nucleoplasm; cytosol

Molecular Function: protein serine/threonine kinase activity; protein binding; caspase inhibitor activity; magnesium ion binding; protein kinase binding; ATP binding; protein kinase activity

Biological Process: axon guidance; central nervous system development; nerve growth factor receptor signaling pathway; stress-activated MAPK cascade; response to lipopolysaccharide; toll-like receptor 3 signaling pathway; negative regulation of caspase activity; signal transduction; protein amino acid phosphorylation; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; synaptic transmission; skeletal development; toll-like receptor 4 signaling pathway; regulation of transcription in response to stress; MyD88-independent toll-like receptor signaling pathway; regulation of translation in response to stress; cell cycle; positive regulation of cell growth; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway; positive regulation of cell differentiation; negative regulation of apoptosis

Disease: Mental Retardation, X-linked 19; Coffin-lowry Syndrome