Western Blot (WB)
(Western blot detection of RAIDD in K562 cell lysates using RAIDD Rabbit mAb(1:1000 diluted). Predicted band size:23kDa. Observed band size:23kDa.)
Rabbit anti-Human, Rat RAIDD Monoclonal Antibody | anti-CRADD antibody
RAIDD Rabbit mAb
ICC/IF: 1:20-1:50
FC/FACS: 1:20
IP: 1:20
Western Blot (WB)
(Western blot detection of RAIDD in K562 cell lysates using RAIDD Rabbit mAb(1:1000 diluted). Predicted band size:23kDa. Observed band size:23kDa.)
Western Blot (WB)
(Western blot detection of RAIDD in K562 cell lysates using RAIDD Rabbit mAb(1:1000 diluted). Predicted band size:23kDa. Observed band size:23kDa.)
Adapter protein that associates with PIDD1 and the caspase CASP2 to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis (PubMed:9044836, PubMed:15073321, PubMed:16652156, PubMed:17159900, PubMed:17289572). Also recruits CASP2 to the TNFR-1 signaling complex through its interaction with RIPK1 and TRADD and may play a role in the tumor necrosis factor-mediated signaling pathway (PubMed:8985253).
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a death domain (CARD/DD)-containing protein and has been shown to induce cell apoptosis. Through its CARD domain, this protein interacts with, and thus recruits, caspase 2/ICH1 to the cell death signal transduction complex that includes tumor necrosis factor receptor 1 (TNFR1A), RIPK1/RIP kinase, and numbers of other CARD domain-containing proteins. [provided by RefSeq, Jul 2008]
Uniprot Description
CRADD: Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex. Defects in CRADD are the cause of mental retardation autosomal recessive type 34 (MRT34). A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. MRT34 is a non- syndromic form. Affected individuals have mildly delayed development and significantly impaired cognitive function, precluding independent living and self-care. Speech is rudimentary, but articulate; autism is not present.
Protein type: Adaptor/scaffold; Apoptosis
Chromosomal Location of Human Ortholog: 12q21.33-q23.1
Cellular Component: cytoplasm; nucleus
Molecular Function: protein binding, bridging; protein binding; protease binding
Biological Process: caspase activation; induction of apoptosis via death domain receptors; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
Disease: Mental Retardation, Autosomal Recessive 34
Research Articles on CRADD
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Product Notes
The CRADD cradd (Catalog #AAA4752992) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The RAIDD Rabbit mAb reacts with Human, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's RAIDD can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow Cytometry (FC/FACS), Immunoprecipitation (IP). WB: 1:1000-1:2000 ICC/IF: 1:20-1:50 FC/FACS: 1:20 IP: 1:20. Researchers should empirically determine the suitability of the CRADD cradd for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "RAIDD, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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