Mouse anti-Human RAD51 / RECA Monoclonal Antibody | anti-RAD51 antibody

Mouse Monoclonal [clone 13E4] (IgG1) to Human RAD51 / RECA

Cat. Num. AAA246410

• Gene Names: RAD51; RECA; BRCC5; MRMV2; HRAD51; RAD51A; HsRad51; HsT16930
• Reactivity: Human
• Applications: Immunohistochemistry, Western Blot
• Purity: Protein G Purified
• Synonyms: RAD51 / RECA; Monoclonal Antibody; Mouse Monoclonal [clone 13E4] (IgG1) to Human RAD51 / RECA; Anti-RAD51 / RECA Antibody (clone 13E4) IHC-plus; RAD51; BRCC5; HsT16930; RAD51 homolog A; RAD51 homolog (S. cerevisiae); RecA; E Coli; homolog of; RecA-like protein; Recombination protein A; MRMV2; HRAD51; HsRad51; RAD51A; RECA; Human RAD51; anti-RAD51 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 13E4
• Specificity: Recombinant human Rad51 protein.
• Purity/Purification: Protein G Purified
• Form/Format: PBS, pH 7.2. No preservative added.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 339

• Applicable Applications for anti-RAD51 antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
• Application Notes: IHC-P (5 ug/ml), WB
• Target Species: Human
• Immunogen Description: Recombinant human RAD51.
• Immunogen Type: Recombinant protein
• Immunogen: RAD51 / RECA antibody was raised against recombinant human RAD51.
• Preparation and Storage: Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.

Immunohistochemistry (IHC)

(Anti-RAD51 antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Immunohistochemistry (IHC)

(Anti-RAD51 antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Related Product Information for anti-RAD51 antibody

The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA.

NCBI and Uniprot Product Information

• NCBI GI #: 19924133
• NCBI GeneID: 5888
• NCBI Accession #: NP_002866.2
• NCBI GenBank Nucleotide #: NM_002875.4
• UniProt Accession #: Q06609; Q6FHX9; Q6ZNA8; Q9BV60; B0FXP0; B2R8T6
• Molecular Weight: 36,780 Da
• NCBI Official Full Name: DNA repair protein RAD51 homolog 1 isoform 1
• NCBI Official Synonym Full Names: RAD51 recombinase
• NCBI Official Symbol: RAD51
• NCBI Official Synonym Symbols: RECA; BRCC5; MRMV2; HRAD51; RAD51A; HsRad51; HsT16930
• NCBI Protein Information: DNA repair protein RAD51 homolog 1; RAD51 homolog A; RecA-like protein; recombination protein A; RecA, E. coli, homolog of; BRCA1/BRCA2-containing complex, subunit 5
• UniProt Protein Name: DNA repair protein RAD51 homolog 1
• Protein Family: DNA repair protein
• UniProt Gene Name: RAD51
• UniProt Synonym Gene Names: RAD51A; RECA; HsRAD51; hRAD51
• UniProt Entry Name: RAD51_HUMAN

NCBI Description

The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

Uniprot Description

RAD51: a member of the RAD51 protein family. Involved in the homologous recombination and repair of DNA. Interacts with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. Interacts with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both its intracellular localization and DNA-binding ability. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Defects in RAD51 are associated with breast cancer. Two alternatively spliced isoforms have been reported.

Protein type: DNA repair, damage; Mitochondrial

Chromosomal Location of Human Ortholog: 15q15.1

Cellular Component: nucleoplasm; lateral element; nuclear chromosome; PML body; condensed nuclear chromosome; mitochondrion; mitochondrial matrix; perinuclear region of cytoplasm; cytoplasm; nucleolus; microtubule organizing center; condensed chromosome; nucleus

Molecular Function: protein C-terminus binding; identical protein binding; protein binding; double-stranded DNA binding; damaged DNA binding; ATP binding; single-stranded DNA-dependent ATPase activity; single-stranded DNA binding

Biological Process: DNA unwinding during replication; meiosis; mitotic recombination; DNA recombinase assembly; double-strand break repair; meiotic recombination; positive regulation of DNA ligation; DNA repair; response to DNA damage stimulus; protein homooligomerization; double-strand break repair via homologous recombination; DNA recombination

Disease: Breast Cancer; Mirror Movements 2