Rabbit anti-Human PTP4A2  Monoclonal Antibody | anti-PTP4A2  antibody

Rabbit anti Human PTP4A2  Monoclonal Antibody

Cat. Num. AAA2544406

• Gene Names: PTP4A2; HH13; OV-1; PRL2; HH7-2; PRL-2; PTP4A; HU-PP-1; PTPCAAX2; ptp-IV1a; ptp-IV1b
• Reactivity: Human
• Applications: ELISA
• Synonyms: PTP4A2 ; Monoclonal Antibody; Rabbit anti Human PTP4A2 Monoclonal Antibody; anti-PTP4A2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG
• Sequence Length: 136

• Applicable Applications for anti-PTP4A2 antibody: ELISA (EIA)
• Application Notes: ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Human PRL-2/PTP4A2.
• Immunogen: Recombinant Human PRL-2/PTP4A2 Protein
• Buffer: 0.2 mum filtered solution in PBS
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-PTP4A2  antibody

PRL-2 (Protein-tyrosine phosphatase of regenerating liver 2), also known as PTP4A2 (Protein tyrosine phosphatase type IVA, member 2), is a member of PTP family and has an important function in controlling cell growth. PRL-2 phosphatases may be multifunctional enzymes with diverse roles in a variety of tissue and cell types. The phosphatase of regenerating liver (PRL) family, comprising PRL-1, PRL-2 and PRL-3, is a group of prenylated phosphatases that are candidate cancer biomarkers and therapeutic targets. PRL-1, PRL-2, and PRL-3 represent a novel class of protein-tyrosine phosphatase with a C-terminal prenylation motif. They are three closely related intracellular enzymes that possess the PTP active site signature sequence CX 5R. The PRL-2 mRNA is elevated in primary breast tumors relative to matched normal tissue, and also dramatically elevated in metastatic lymph nodes compared with primary tumors. PRL-2 plays a role in breast cancer progression. PRL-2 is a pathogenic molecule in hematopoietic malignancies and suggest its potential as a novel therapeutic target.

NCBI and Uniprot Product Information

• NCBI GI #: 304361764
• NCBI GeneID: 8073
• NCBI GenBank Nucleotide #: NM_001195101.1
• Molecular Weight: 16,367 Da
• NCBI Official Full Name: protein tyrosine phosphatase type IVA 2 isoform 4
• NCBI Official Synonym Full Names: protein tyrosine phosphatase type IVA, member 2
• NCBI Official Symbol: PTP4A2
• NCBI Official Synonym Symbols: HH13; OV-1; PRL2; HH7-2; PRL-2; PTP4A; HU-PP-1; PTPCAAX2; ptp-IV1a; ptp-IV1b
• NCBI Protein Information: protein tyrosine phosphatase type IVA 2
• UniProt Protein Name: Protein tyrosine phosphatase type IVA 2
• UniProt Gene Name: PTP4A2
• UniProt Synonym Gene Names: PRL2; PTPCAAX2; PRL-2
• UniProt Entry Name: TP4A2_HUMAN

NCBI Description

The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 11, 12 and 17. [provided by RefSeq, Aug 2010]

Uniprot Description

PTP4A2: Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB. Belongs to the protein-tyrosine phosphatase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor)

Chromosomal Location of Human Ortholog: 1p35

Cellular Component: cytoplasm; nucleus

Molecular Function: prenylated protein tyrosine phosphatase activity