PTGER2 recombinant antibody

PTGER2 Antibody

Cat. Num. AAA7136702

• Gene Names: PTGER2; EP2
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: Affinity-chromatography
• Synonyms: PTGER2; Monoclonal Recombinant Antibody; PTGER2 Antibody; Prostaglandin E2 receptor EP2 subtype (PGE receptor EP2 subtype) (PGE2 receptor EP2 subtype) (Prostanoid EP2 receptor); PTGER2 recombinant antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: Rabbit IgG
• Clone Number: 8D8
• Purity/Purification: Affinity-chromatography
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, PH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

• Applicable Applications for PTGER2 recombinant antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: IHC: 1:50-1:200
• Antibody Type: Recombinant Antibody
• Conjugation: Non-conjugated
• Immunogen: A synthesized peptide derived from human PTGER2
• Preparation and Storage: Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.

Immunohistochemistry (IHC)

(IHC image diluted at 1:100 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4 degree C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.)

Immunohistochemistry (IHC)

(IHC image diluted at 1:100 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4 degree C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.)

Related Product Information for PTGER2 recombinant antibody

Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle.

Product Categories/Family for PTGER2 recombinant antibody

Cancer; Metabolism; Signal transduction

NCBI and Uniprot Product Information

• NCBI GI #: 31881630
• NCBI GeneID: 5732
• NCBI Accession #: NP_000947.2
• NCBI GenBank Nucleotide #: NM_000956.3
• UniProt Accession #: P43116; Q52LG8; D3DSC0
• Molecular Weight: 39,761 Da
• NCBI Official Full Name: prostaglandin E2 receptor EP2 subtype
• NCBI Official Synonym Full Names: prostaglandin E receptor 2 (subtype EP2), 53kDa
• NCBI Official Symbol: PTGER2
• NCBI Official Synonym Symbols: EP2
• NCBI Protein Information: prostaglandin E2 receptor EP2 subtype; prostanoid EP2 receptor; PGE receptor EP2 subtype; PGE2 receptor EP2 subtype
• UniProt Protein Name: Prostaglandin E2 receptor EP2 subtype
• Protein Family: Prostaglandin E2 receptor
• UniProt Gene Name: PTGER2
• UniProt Synonym Gene Names: PGE receptor EP2 subtype
• UniProt Entry Name: PE2R2_HUMAN

NCBI Description

This gene encodes a receptor for prostaglandin E2, a metabolite of arachidonic acid which has different biologic activities in a wide range of tissues. Mutations in this gene are associated with aspirin-induced susceptibility to asthma. [provided by RefSeq, Oct 2009]

Uniprot Description

PTGER2: Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, integral; Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 14q22

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: prostaglandin E receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; response to lipopolysaccharide; G-protein signaling, adenylate cyclase activating pathway; regulation of cell proliferation

Disease: Asthma, Nasal Polyps, And Aspirin Intolerance