Mouse Protein MSS1 Monoclonal Antibody | anti-PSMC2 antibody

Anti-Protein MSS1 Antibody

Cat. Num. AAA415327

• Gene Names: PSMC2; S7; MSS1; Nbla10058
• Applications: ELISA, Western Blot
• Purity: Affinity purified
• Synonyms: Protein MSS1; Monoclonal Antibody; Anti-Protein MSS1 Antibody; anti-PSMC2 antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG1
• Specificity: Anti-Protein MSS1 recognizes Protein MSS1 expression in Hela whole cell lysate.
• Purity/Purification: Affinity purified
• Form/Format: Liquid
• Concentration: 100ug/100ul (varies by lot)
• Sequence Length: 2846

• Applicable Applications for anti-PSMC2 antibody: ELISA (EIA), Western Blot (WB-Ce)
• Application Notes: WB: 1:1000 analysis of Protein MSS1 expression in Hela whole cell lysate with Anti-Protein MSS1
• Raised In: Purified mouse monoclonal antibody generated using E.coli expressed recombinant protein Protein MSS1 as immunogen.
• Storage Buffer: citrate-tris-HCl buffer pH7.0 with 0.02% Proclin 300.
• Immunogen: Recombinant protein corresponding to full length Protein MSS1.
• Preparation and Storage: This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Testing Data

References

None

NCBI and Uniprot Product Information

• NCBI GI #: 325053650
• NCBI GeneID: 5701
• NCBI Accession #: NP_002794.1
• NCBI GenBank Nucleotide #: NM_002803
• Molecular Weight: 33,274 Da
• NCBI Official Full Name: Homo sapiens proteasome (prosome, macropain) 26S subunit, ATPase, 2 (PSMC2), transcript variant 1, mRNA
• NCBI Official Synonym Full Names: proteasome (prosome, macropain) 26S subunit, ATPase, 2
• NCBI Official Symbol: PSMC2
• NCBI Official Synonym Symbols: S7; MSS1; Nbla10058
• NCBI Protein Information: 26S protease regulatory subunit 7; 26S proteasome AAA-ATPase subunit RPT1; mammalian suppressor of sgv-1 of yeast; protease 26S subunit 7; proteasome 26S subunit ATPase 2; proteasome 26S subunit, ATPase, 2; putative protein product of Nbla10058
• UniProt Protein Name: 26S protease regulatory subunit 7
• Protein Family: Protein
• UniProt Gene Name: PSMC2
• UniProt Entry Name: PRS7_HUMAN

NCBI Description

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with several of the basal transcription factors so, in addition to participation in proteasome functions, this subunit may participate in the regulation of transcription. This subunit may also compete with PSMC3 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2011]

Uniprot Description

RPT1: The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. In case of HIV-1 infection, positive modulator of Tat-mediated transactivation. Belongs to the AAA ATPase family.

Protein type: Proteasome complex; Protease

Chromosomal Location of Human Ortholog: 7q22.1-q22.3

Cellular Component: proteasome complex; nucleoplasm; membrane; cytoplasm; nucleus; cytosol

Molecular Function: protein binding; ATPase activity; ATP binding

Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; ubiquitin-dependent protein catabolic process; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; protein polyubiquitination; viral reproduction; apoptosis; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; regulation of apoptosis; osteoblast differentiation; antigen processing and presentation of peptide antigen via MHC class I; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; gene expression; mitotic cell cycle; regulation of amino acid metabolic process; G1/S transition of mitotic cell cycle; negative regulation of apoptosis