Mouse anti-Human Properdin Monoclonal Antibody | anti-CFP antibody

Properdin (Complement factor P, CFP, PFC)

Cat. Num. AAA609439

• Reactivity: Human
• Applications: ELISA
• Purity: Affinity Purified; Purified by Protein A Affinity Chromatography.
• Synonyms: Properdin; Monoclonal Antibody; Properdin (Complement factor P; CFP; PFC); Anti -Properdin (Complement factor P; anti-CFP antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 10K327
• Specificity: Recognizes human properdin.
• Purity/Purification: Affinity Purified; Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, 0.1% sodium azide.

• Applicable Applications for anti-CFP antibody: ELISA (EL/EIA)
• Application Notes: Suitable for use in ELISA.; Dilution: ELISA (Indirect): 1ug/ml
• Immunogen: Human properdin purified from blood.
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage, aliquot to avoid repeated freezing and thawing and freeze at -70 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquots are stable for at least 12 months.

Related Product Information for anti-CFP antibody

Properdin in plasma is a mixture of cyclic dimers, trimers and tetramers. The molecular weight of the glycosylated monomer is 53kD. Properdin is a regulator protein of the alternative complement pathway. It stabilizes the C3 convertase excerting its effect by binding to C3b in the C3bBb complex and thereby inhibiting cleavage of C3b by factor I and increasing the affinity for factor B. Serum concentration is approximately 25ug/ml.

Product Categories/Family for anti-CFP antibody

Antibodies; Abs to Complement

NCBI and Uniprot Product Information

• NCBI GI #: 35680
• UniProt Accession #: P27918; O15134; O15135; O15136; O75826
• Molecular Weight: 51,276 Da
• NCBI Official Full Name: properdin
• UniProt Protein Name: Properdin
• Protein Family: Properdin
• UniProt Gene Name: CFP
• UniProt Synonym Gene Names: PFC
• UniProt Entry Name: PROP_HUMAN

NCBI Description

This gene encodes a plasma glycoprotein that positively regulates the alternative complement pathway of the innate immune system. This protein binds to many microbial surfaces and apoptotic cells and stabilizes the C3- and C5-convertase enzyme complexes in a feedback loop that ultimately leads to formation of the membrane attack complex and lysis of the target cell. Mutations in this gene result in two forms of properdin deficiency, which results in high susceptibility to meningococcal infections. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Feb 2009]

Uniprot Description

CFP: A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes. Defects in CFP are the cause of properdin deficiency (PFD). PFD results in higher susceptibility to bacterial infections; especially to meningococcal infections. Three phenotypes have been reported: complete deficiency (type I), incomplete deficiency (type II), and dysfunction of properdin (type III).

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: Xp11.4

Cellular Component: extracellular matrix; extracellular space; endoplasmic reticulum lumen; extracellular region

Biological Process: protein amino acid O-linked glycosylation; cellular protein metabolic process; defense response to bacterium; complement activation, alternative pathway; regulation of complement activation; innate immune response; immune response; post-translational protein modification; complement activation

Disease: Properdin Deficiency, X-linked