Mouse Potassium Large Conductance Calcium-activated Channel, Subfamily M, Beta Member 2 Monoclonal Antibody | anti-KCNMB1 antibody

Potassium Large Conductance Calcium-activated Channel, Subfamily M, Beta Member 2 (BK Channel Subunit beta 2, BKbeta2, Calcium-activated Potassium Channel beta 3 Subunit, Calcium-activated Potassium Channel Subfamily M Subunit beta 2, Calcium-activated Po

Cat. Num. AAA609903

• Gene Names: KCNMB1; SLO-BETA; hslo-beta; K(VCA)beta
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunoprecipitation, Immunohistochemistry
• Purity: Affinity Purified; Purified by Protein G affinity chromatography.
• Synonyms: Potassium Large Conductance Calcium-activated Channel; Subfamily M; Beta Member 2; Monoclonal Antibody; Beta Member 2 (BK Channel Subunit beta 2; BKbeta2; Calcium-activated Potassium Channel beta 3 Subunit; Calcium-activated Potassium Channel Subfamily M Subunit beta 2; Calcium-activated Po; Anti -Potassium Large Conductance Calcium-activated Channel; anti-KCNMB1 antibody

• Host: Mouse
• Reactivity: Human, Mouse, Rat
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 10F761
• Specificity: Recognizes mouse BKBeta2. Species Crossreactivity: human, rat. No cross-reactivity against
• Purity/Purification: Affinity Purified; Purified by Protein G affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH7.4, 50% glycerol and 0.09% sodium azide.

• Applicable Applications for anti-KCNMB1 antibody: Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC)
• Application Notes: Dilution: Western Blot:1-10ug/ml; Immunohistochemistry:0.1-1ug/ml
• Immunogen: Fusion protein aa 1-41 (N-terminus) and 218-235 (C-terminus) of mouse BKBeta2 (accession number Q9CZM9)
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-KCNMB1 antibody

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or

Product Categories/Family for anti-KCNMB1 antibody

Antibodies; Abs to Ion Channel

NCBI and Uniprot Product Information

• NCBI GI #: 15422167
• NCBI GeneID: 3779
• UniProt Accession #: Q16558; O00707; O00708; P78475; Q53YR0; Q8TAX3; Q93005; AAB39373
• Molecular Weight: 21,797 Da
• NCBI Official Full Name: potassium large conductance calcium-activated channel
• NCBI Official Synonym Full Names: potassium large conductance calcium-activated channel, subfamily M, beta member 1
• NCBI Official Symbol: KCNMB1
• NCBI Official Synonym Symbols: SLO-BETA; hslo-beta; K(VCA)beta
• NCBI Protein Information: calcium-activated potassium channel subunit beta-1; BKbeta; hbeta1; BKbeta1; slo-beta-1; k(VCA)beta-1; OTTHUMP00000160996; BK channel beta subunit; BK channel subunit beta-1; Maxi K channel beta subunit; maxi K channel subunit beta-1; charybdotoxin receptor subunit beta-1; large conductance Ca2+-activated K+ channel beta 1 subunit; calcium-activated potassium channel, subfamily M subunit beta-1
• UniProt Protein Name: Calcium-activated potassium channel subunit beta-1
• Protein Family: Putative calcium-activated potassium channel
• UniProt Gene Name: KCNMB1
• UniProt Entry Name: KCMB1_HUMAN

NCBI Description

MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the product of this gene, the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. [provided by RefSeq]

Uniprot Description

KCNMB1: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate. Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB1 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 5q34

Cellular Component: voltage-gated potassium channel complex; plasma membrane

Molecular Function: calcium-activated potassium channel activity; potassium channel regulator activity

Biological Process: synaptic transmission; detection of calcium ion; blood coagulation; potassium ion transport

Disease: Hypertension, Diastolic, Resistance To