Mouse anti-Human PMPCB Monoclonal Antibody | anti-PMPCB antibody

PMPCB (MPPB, Mitochondrial-processing Peptidase Subunit beta, Beta-MPP, P-52, MPPP52) (AP)

Cat. Num. AAA6133026

• Gene Names: PMPCB; MPPB; P-52; MPP11; MPPP52; Beta-MPP
• Reactivity: Human
• Applications: ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: PMPCB; Monoclonal Antibody; PMPCB (MPPB; Mitochondrial-processing Peptidase Subunit beta; Beta-MPP; P-52; MPPP52) (AP); anti-PMPCB antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1,k
• Clone Number: 3C3
• Specificity: Recognizes human PMPCB.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).

• Applicable Applications for anti-PMPCB antibody: ELISA (EIA)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: Partial recombinant corresponding to aa161-269 from PMPCB (NP_004270) with GST tag. MW of the GST tag alone is 26kD.
• Immunogen Sequence: IQNSTLGEAEIERERGVILREMQEVETNLQEVVFDYLHATAYQNTALGRTILGPTENIKSISRKDLVDYITTHYKGPRIVLAAAGGVSHDELLDLAKFHFGDSLCTHKG
• Conjugate: AP
• Preparation and Storage: Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Testing Data

(Detection limit for recombinant GST tagged PMPCB is 0.03ng/ml as a capture antibody.)

Related Product Information for anti-PMPCB antibody

PMPCB is a member of the peptidase M16 family and encodes a protein with a zinc-binding motif. This protein is located in the mitochondrial matrix and catalyzes the cleavage of the leader peptides of precursor proteins newly imported into the mitochondria, though it only functions as part of a heterodimeric complex.

Product Categories/Family for anti-PMPCB antibody

Antibodies; Enzymes; Peptidase

NCBI and Uniprot Product Information

• NCBI GI #: 94538354
• NCBI GeneID: 9512
• NCBI Accession #: NP_004270
• NCBI GenBank Nucleotide #: NM_004279
• UniProt Accession #: O75439; O60416; Q96FV4
• Molecular Weight: 54,366 Da
• NCBI Official Full Name: mitochondrial-processing peptidase subunit beta
• NCBI Official Synonym Full Names: peptidase, mitochondrial processing beta subunit
• NCBI Official Symbol: PMPCB
• NCBI Official Synonym Symbols: MPPB; P-52; MPP11; MPPP52; Beta-MPP
• NCBI Protein Information: mitochondrial-processing peptidase subunit beta
• UniProt Protein Name: Mitochondrial-processing peptidase subunit beta
• UniProt Gene Name: PMPCB
• UniProt Synonym Gene Names: MPPB
• UniProt Entry Name: MPPB_HUMAN

NCBI Description

This gene is a member of the peptidase M16 family and encodes a protein with a zinc-binding motif. This protein is located in the mitochondrial matrix and catalyzes the cleavage of the leader peptides of precursor proteins newly imported into the mitochondria, though it only functions as part of a heterodimeric complex. [provided by RefSeq, Jul 2008]

Uniprot Description

Function: Cleaves presequences (transit peptides) from mitochondrial protein precursors

By similarity.

Catalytic activity: Release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2.

Cofactor: Binds 1 zinc ion per subunit

By similarity.

Subunit structure: Heterodimer of alpha and beta subunits

By similarity.

Subcellular location: Mitochondrion matrix

By similarity.

Sequence similarities: Belongs to the peptidase M16 family.