Mouse anti-Human PDCD11 Monoclonal Antibody | anti-PDCD11 antibody

PDCD11 (Protein RRP5 Homolog, Programmed Cell Death Protein 11, NF-kappa-B-binding Protein, NFBP, KIAA0185)

Cat. Num. AAA641594

• Gene Names: PDCD11; ALG4; NFBP; RRP5; ALG-4
• Reactivity: Human
• Applications: ELISA
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: PDCD11; Monoclonal Antibody; PDCD11 (Protein RRP5 Homolog; Programmed Cell Death Protein 11; NF-kappa-B-binding Protein; NFBP; KIAA0185); Anti -PDCD11 (Protein RRP5 Homolog; anti-PDCD11 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1,k
• Clone Number: 3E12
• Specificity: Recognizes human PDCD11.
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2.
• Sequence: MANLEESFPRGGTRKIHKPEKAFQQSVEQDNLFDISTEEGSTKRKKSQKGPAKTKKLKIEKRESSKSAREKFEILSVESLCEGMRILGCVKEVNELELVISLPNGLQGFV

• Applicable Applications for anti-PDCD11 antibody: ELISA (EL/EIA)
• Application Notes: Suitable for use in ELISA.
• Immunogen: Partial recombinant corresponding to aa1-111 from PDCD11 (AAH49838) with GST tag. MW of the GST tag alone is 26kD.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Testing Data

(Detection limit for recombinant GST tagged PDCD11 is ~0.1ng/ml as a capture antibody.)

Related Product Information for anti-PDCD11 antibody

Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA. Involved in the biogenesis of rRNA.

Product Categories/Family for anti-PDCD11 antibody

Antibodies; Abs to Apoptosis

NCBI and Uniprot Product Information

• NCBI GI #: 70980549
• NCBI GeneID: 22984
• NCBI Accession #: NP_055791.1
• NCBI GenBank Nucleotide #: NM_014976.1
• UniProt Accession #: Q14690; Q2TA92; Q5W093; Q6P2J3; Q86VQ8; Q9H4P1
• Molecular Weight: 208,701 Da
• NCBI Official Full Name: protein RRP5 homolog
• NCBI Official Synonym Full Names: programmed cell death 11
• NCBI Official Symbol: PDCD11
• NCBI Official Synonym Symbols: ALG4; NFBP; RRP5; ALG-4
• NCBI Protein Information: protein RRP5 homolog; apoptosis-linked gene 4; NF-kappa-B-binding protein; programmed cell death protein 11
• UniProt Protein Name: Protein RRP5 homolog
• Protein Family: Protein
• UniProt Gene Name: PDCD11
• UniProt Synonym Gene Names: KIAA0185; NFBP
• UniProt Entry Name: RRP5_HUMAN

NCBI Description

PDCD11 is a NF-kappa-B (NFKB1; 164011)-binding protein that colocalizes with U3 RNA (MIM 180710) in the nucleolus and is required for rRNA maturation and generation of 18S rRNA (Sweet et al., 2003 [PubMed 14624448]; Sweet et al., 2008 [PubMed 17654514]).[supplied by OMIM, Oct 2008]

Uniprot Description

PDCD11: Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA.

Protein type: RNA-binding; Nucleolus

Chromosomal Location of Human Ortholog: 10q24.33

Cellular Component: nucleolus; nucleus; cytosol

Molecular Function: protein binding; transcription factor binding

Biological Process: mRNA processing; rRNA processing