Mouse PAPPA Monoclonal Antibody | anti-PAPPA antibody

PAPPA antibody

Cat. Num. AAA838539

• Gene Names: PAPPA; PAPA; DIPLA1; PAPP-A; PAPPA1; ASBABP2; IGFBP-4ase
• Applications: ELISA, Immunoprecipitation
• Purity: PAPPA antibody was purified by Protein A chromatography.
• Synonyms: PAPPA; Monoclonal Antibody; PAPPA antibody; Monoclonal PAPPA; Anti-PAPPA; PAPP-A; Pregnancy Associated Plasma Protein A; PAPP A; Anti PAPPA; anti-PAPPA antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG2a
• Clone Number: M18612PP4
• Specificity: Human PAPPA
• Purity/Purification: PAPPA antibody was purified by Protein A chromatography.
• Form/Format: Supplied in PBS, pH 7.4, 0.1 % sodium azide (NaN3)
• Sequence Length: 186

• Applicable Applications for anti-PAPPA antibody: ELISA (EIA), Immunoassays, Immunoprecipitation (IP)
• Application Notes: MBS838539 can be used in a sandwich immunoassay as a conjugate antibody in conjunction with MBS531595 as the coating antibody
• Biological Significance: Pregnancy-associated plasma protein A, pappalysin 1, also known as PAPPA, is a protein used in screening tests for Down syndrome. PAPPA is a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses
• Biohazard Information: This product is sold as an antibody preparation for research use only. Standard Laboratory Practices should be followed when handling this material. Contains sodium azide (0.1 %) as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
• Immunogen: PAPPA antibody was raised in mouse using purified human PAPP-A/proMBP complex as the immunogen.
• Preparation and Storage: Store at 4 degree C

Related Product Information for anti-PAPPA antibody

Mouse monoclonal PAPPA antibody

Product Categories/Family for anti-PAPPA antibody

Proteases; Inhibitors; & Enzymes

NCBI and Uniprot Product Information

• NCBI GI #: 55139852
• NCBI GeneID: 5069
• Molecular Weight: 180,973 Da
• NCBI Official Full Name: pregnacy-associated plasma protein A, partial
• NCBI Official Synonym Full Names: pregnancy-associated plasma protein A, pappalysin 1
• NCBI Official Symbol: PAPPA
• NCBI Official Synonym Symbols: PAPA; DIPLA1; PAPP-A; PAPPA1; ASBABP2; IGFBP-4ase
• NCBI Protein Information: pappalysin-1
• UniProt Protein Name: Pappalysin-1
• Protein Family: Pappalysin
• UniProt Gene Name: PAPPA
• UniProt Synonym Gene Names: IGF-dependent IGFBP-4 protease; IGFBP-4ase; PAPP-A
• UniProt Entry Name: PAPP1_HUMAN

NCBI Description

This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses. [provided by RefSeq, Jul 2008]

Uniprot Description

PAPPA: Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. Belongs to the peptidase M43B family.

Protein type: Secreted, signal peptide; EC 3.4.24.79; Secreted; Protease

Chromosomal Location of Human Ortholog: 9q33.2

Cellular Component: membrane; extracellular region

Molecular Function: zinc ion binding; metallopeptidase activity; metalloendopeptidase activity

Biological Process: cellular protein metabolic process; female pregnancy; proteolysis; cell differentiation