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Immunohistochemistry (IHC) (Anti-THOC1 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Mouse anti-Human p84 / THOC1 Monoclonal Antibody | anti-p84 antibody

Mouse Monoclonal [clone 5E10] (IgG2b) to Human p84 / THOC1

Gene Names
THOC1; P84; HPR1; P84N5
Reactivity
Human
Applications
Immunohistochemistry, Immunofluorescence, Western Blot, Immunoprecipitation
Purity
Protein G Purified
Synonyms
p84 / THOC1; Monoclonal Antibody; Mouse Monoclonal [clone 5E10] (IgG2b) to Human p84 / THOC1; Anti-p84 / THOC1 Antibody (aa15-374; clone 5E10) IHC-plus; THOC1; HTREX84; Nuclear matrix protein p84; p84; THO complex subunit 1; THO1; HPR1; p84N5; THO complex 1; Human p84; anti-p84 antibody
Ordering
For Research Use Only!
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG2b
Clone Number
5E10
Specificity
Amino acids 15-374 of human p84 expressed in E Coli.
Purity/Purification
Protein G Purified
Form/Format
PBS, pH 7.4. Contains no preservatives.
Concentration
1 mg/ml (varies by lot)
Sequence Length
657
Applicable Applications for anti-p84 antibody
Immunohistochemistry (IHC - Paraffin), Immunofluorescence (IF), Western Blot (WB), Immunoprecipitation (IP)
Application Notes
IF, IHC-P (5 ug/ml), IP, WB
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
Target Species
Human
Immunogen Description
Recombinant human THOC1.
Immunogen Type
Recombinant protein
Immunogen
p84 / THOC1 antibody was raised against recombinant human THOC1.
Antigen Modification
aa15-374
Preparation and Storage
Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.

Immunohistochemistry (IHC)

(Anti-THOC1 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Immunohistochemistry (IHC) (Anti-THOC1 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
43,359 Da
NCBI Official Full Name
THO complex subunit 1
NCBI Official Synonym Full Names
THO complex 1
NCBI Official Symbol
THOC1
NCBI Official Synonym Symbols
P84; HPR1; P84N5
NCBI Protein Information
THO complex subunit 1; tho1; hTREX84; nuclear matrix protein p84
UniProt Protein Name
THO complex subunit 1
UniProt Gene Name
THOC1
UniProt Synonym Gene Names
HPR1; Tho1; p84N5
UniProt Entry Name
THOC1_HUMAN

NCBI Description

HPR1 is part of the TREX (transcription/export) complex, which includes TEX1 (MIM 606929), THO2 (MIM 300395), ALY (MIM 604171), and UAP56 (MIM 142560).[supplied by OMIM, Nov 2010]

Uniprot Description

Tho1: a protein associated the nuclear matrix. Part of the TREX (transcription/export) complex. The TREX complex is recruited to transcribed genes and travels with the RNA polymerase during elongation. It may physically link proteins that function in transcription and in RNA export.

Protein type: Spliceosome

Chromosomal Location of Human Ortholog: 18p11.32

Cellular Component: nucleoplasm; intercellular bridge; nuclear matrix; cytoplasm; nuclear speck; nucleus

Molecular Function: protein binding; DNA binding; RNA binding

Biological Process: RNA processing; mRNA export from nucleus; transcription, DNA-dependent; negative regulation of isotype switching to IgA isotypes; apoptosis; RNA splicing; positive regulation of RNA elongation; regulation of DNA recombination; intronless viral mRNA export from host nucleus; signal transduction; mRNA processing; regulation of RNA elongation; replication fork processing

Research Articles on p84

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Product Notes

The p84 thoc1 (Catalog #AAA245087) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Mouse Monoclonal [clone 5E10] (IgG2b) to Human p84 / THOC1 reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's p84 / THOC1 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC - Paraffin), Immunofluorescence (IF), Western Blot (WB), Immunoprecipitation (IP). IF, IHC-P (5 ug/ml), IP, WB Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.. Researchers should empirically determine the suitability of the p84 thoc1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "p84 / THOC1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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