Testing Data
Rat anti-Human ORC2 Monoclonal Antibody | anti-ORC2 antibody
Rat Anti-ORC2 [3G6]
Testing Data
Testing Data
NCBI and Uniprot Product Information
NCBI Description
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. This protein forms a core complex with ORC3, -4, and -5. It also interacts with CDC45 and MCM10, which are proteins known to be important for the initiation of DNA replication. This protein has been demonstrated to specifically associate with the origin of replication of Epstein-Barr virus in human cells, and is thought to be required for DNA replication from viral origin of replication. Alternatively spliced transcript variants have been found, one of which is a nonsense-mediated mRNA decay candidate. [provided by RefSeq, Oct 2010]
Uniprot Description
ORC2: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. ORC is composed of six subunits. In human, ORC is cell cycle-dependent regulated: it is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase. Interacts with DBF4. Interacts with MCM10. Belongs to the ORC2 family.
Protein type: DNA replication
Chromosomal Location of Human Ortholog: 2q33
Cellular Component: nucleoplasm; heterochromatin; membrane; inner kinetochore of condensed chromosome; plasma membrane; nuclear origin of replication recognition complex; nucleus; origin recognition complex
Molecular Function: protein binding; DNA replication origin binding
Biological Process: DNA replication initiation; negative regulation of transcription from RNA polymerase II promoter; mitotic cell cycle; DNA replication; G1/S transition of mitotic cell cycle
Research Articles on ORC2
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Product Notes
The ORC2 orc2 (Catalog #AAA375157) is an Antibody produced from Rat and is intended for research purposes only. The product is available for immediate purchase. The Rat Anti-ORC2 [3G6] reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's ORC2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunoprecipitation (IP). Optimal antibody dilution should be determined by titration, however as a guideline try; WB: Use at 1:1000. Predicted molecular weight: 66 kDa. Researchers should empirically determine the suitability of the ORC2 orc2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ORC2, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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