Mouse anti-Human NUP98 Monoclonal Antibody | anti-NUP98 antibody

NUP98 (ADIR2, Nuclear pore complex protein Nup98-Nup96 precursor, NUP196) (FITC)

Cat. Num. AAA6145662

• Gene Names: NUP98; ADIR2; NUP96; NUP196; Nup98-96
• Reactivity: Human
• Applications: ELISA
• Purity: Purified
• Synonyms: NUP98; Monoclonal Antibody; NUP98 (ADIR2; Nuclear pore complex protein Nup98-Nup96 precursor; NUP196) (FITC); anti-NUP98 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG2a,k
• Clone Number: 4G2
• Specificity: Recognizes human NUP98.
• Purity/Purification: Purified
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein isothiocyanate (FITC).
• Sequence Length: 752

• Applicable Applications for anti-NUP98 antibody: ELISA (EIA)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: NUP98 (AAH12906, 1-110aa) partial recombinant protein with GST tag. MW of the GST tag alone is 26kD.
• Conjugate: FITC
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-NUP98 antibody

Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98kD nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186kD precursor protein. This cleavage results in the 98kD nucleoporin as well as a 96kD nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98kD nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromsome translocatons in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.

Product Categories/Family for anti-NUP98 antibody

Antibodies; Nuclear Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 211825900
• NCBI GeneID: 4928
• NCBI Official Full Name: NUP98 protein, partial
• NCBI Official Synonym Full Names: nucleoporin 98 and 96 precursor
• NCBI Official Symbol: NUP98
• NCBI Official Synonym Symbols: ADIR2; NUP96; NUP196; Nup98-96
• NCBI Protein Information: nuclear pore complex protein Nup98-Nup96; nuclear pore complex protein Nup98

NCBI Description

Nuclear pore complexes (NPCs) regulate the transport of macromolecules between the nucleus and cytoplasm, and are composed of many polypeptide subunits, many of which belong to the nucleoporin family. This gene belongs to the nucleoporin gene family and encodes a 186 kDa precursor protein that undergoes autoproteolytic cleavage to generate a 98 kDa nucleoporin and 96 kDa nucleoporin. The 98 kDa nucleoporin contains a Gly-Leu-Phe-Gly (GLGF) repeat domain and participates in many cellular processes, including nuclear import, nuclear export, mitotic progression, and regulation of gene expression. The 96 kDa nucleoporin is a scaffold component of the NPC. Proteolytic cleavage is important for targeting of the proteins to the NPC. Translocations between this gene and many other partner genes have been observed in different leukemias. Rearrangements typically result in chimeras with the N-terminal GLGF domain of this gene to the C-terminus of the partner gene. Alternative splicing results in multiple transcript variants encoding different isoforms, at least two of which are proteolytically processed. Some variants lack the region that encodes the 96 kDa nucleoporin. [provided by RefSeq, Feb 2016]