Mouse anti-Human NUMBL Monoclonal Antibody | anti-NUMBL antibody

NUMBL Mouse Monoclonal

Cat. Num. AAA7602151

• Gene Names: NUMBL; NBL; CAG3A; CTG3a; NUMBR; NUMB-R; TNRC23; NUMBLIKE
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Protein A+G purification
• Synonyms: NUMBL; Monoclonal Antibody; NUMBL Mouse Monoclonal; anti-NUMBL antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG2a
• Purity/Purification: >=95% as determined by SDS-PAGE; Protein A+G purification
• Form/Format: Liquid
• Sequence Length: 568

• Applicable Applications for anti-NUMBL antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen: Numb homolog (Drosophila)-like
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human gliomas tissue slide using MBS7602151 (NUMBLIKE Antibody) at dilution of 1:50)

Western Blot (WB)

(L02 cells were subjected to SDS PAGE followed by western blot with MBS7602151 (NUMBLIKE Antibody) at dilution of 1:1000)

NCBI and Uniprot Product Information

• NCBI GI #: 586798132
• NCBI GeneID: 9253
• NCBI Accession #: NP_001276908.1
• NCBI GenBank Nucleotide #: NM_001289979.1
• Molecular Weight: 64,891 Da
• NCBI Official Full Name: numb-like protein isoform b
• NCBI Official Synonym Full Names: NUMB like, endocytic adaptor protein
• NCBI Official Symbol: NUMBL
• NCBI Official Synonym Symbols: NBL; CAG3A; CTG3a; NUMBR; NUMB-R; TNRC23; NUMBLIKE
• NCBI Protein Information: numb-like protein
• UniProt Protein Name: Numb-like protein
• Protein Family: Numb-like protein
• UniProt Gene Name: NUMBL
• UniProt Synonym Gene Names: Numb-R
• UniProt Entry Name: NUMBL_HUMAN

Uniprot Description

NUMBL: Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF- kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons. Interacts (via PTB domain) with MAP3K7IP2 (via C- terminal). Interacts (via C-terminal) with TRAF6 (via TRAF domains). Associates with EPS15 and NOTCH1.

Protein type: Cell development/differentiation

Chromosomal Location of Human Ortholog: 19q13.13-q13.2

Cellular Component: cytoplasm

Molecular Function: protein binding

Biological Process: axonogenesis; cytokine and chemokine mediated signaling pathway; lateral ventricle development; nervous system development; neuroblast division in the subventricular zone; positive regulation of dendrite morphogenesis; positive regulation of neurogenesis; protein metabolic process