Mouse anti-Human NR4A2 Monoclonal Antibody | anti-NR4A2 antibody

Mouse monoclonal antibody Anti-Human NR4A2

Cat. Num. AAA120305

• Gene Names: NR4A2; NOT; RNR1; HZF-3; NURR1; TINUR
• Reactivity: Human
• Applications: Dot Blot, Western Blot
• Synonyms: NR4A2; Monoclonal Antibody; Mouse monoclonal antibody Anti-Human NR4A2; Homo sapiens nuclear receptor subfamily 4; group A; member 2; NOT; RNR1; HZF-3; NURR1; TINUR; anti-NR4A2 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 447C2a
• Form/Format: Mouse monoclonal anti-human NR4A2 antibody in PBS (0.3mM KCI, 1.5mM KH₂PO₄, 140mM NaCL , 8.0 mM Na₂HPO₄ (pH 7.4)) containing 1% bovine serum albumin (BSA) AND 0.05% sodium azide (NaN₃)
• Concentration: 100 ug/ml (1.0 ml) (varies by lot)
• Sequence Length: 3546

• Applicable Applications for anti-NR4A2 antibody: Dot Blot (DB), Western Blot (WB)
• Immunogen: Recombiant
• Preparation: This antibody was purified using protein A column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
• Sterility: Filtered through a 0.22 um membrane.
• Disposal: This antibody solution contains sodium azide (NaN₃) as a preservative. There is a potential hazard that NaN₃ reacts with copper or lead to produce an explosive compound. For safe disposal , the vial has to be washed thoroughly with water.
• Preparation and Storage: Store at 2°C to 8°C for up to 1 year; We recommend storing at -20°C for long term storage; Avoid repeated freeze / thaw cycles.

Western Blot (WB)

Western Blot (WB)

(Detection of human NR4A2 by Western Blot.Samples: Whole cell lysate (25 ug ) from HeLa cells [Lot No. 447C2a-1])

Related Product Information for anti-NR4A2 antibody

This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Four transcript variants encoding four distinct isoforms have been identified for this gene. Additional alternate splice variants may exist, but their full length nature has not been determined. [NCBI Entrez Gene Summary]

NCBI and Uniprot Product Information

• NCBI GI #: 187423888
• NCBI GeneID: 4929
• NCBI Accession #: NP_006177.1
• NCBI GenBank Nucleotide #: NM_006186
• NCBI Official Full Name: Homo sapiens nuclear receptor subfamily 4, group A, member 2 (NR4A2), mRNA
• NCBI Official Synonym Full Names: nuclear receptor subfamily 4, group A, member 2
• NCBI Official Symbol: NR4A2
• NCBI Official Synonym Symbols: NOT; RNR1; HZF-3; NURR1; TINUR
• NCBI Protein Information: nuclear receptor subfamily 4 group A member 2; NGFI-B/nur77 beta-type transcription factor homolog; T-cell nuclear receptor NOT; immediate-early response protein NOT; intermediate-early receptor protein; nuclear receptor related 1; nur related protein-1, human homolog of; orphan nuclear receptor NR4A2; orphan nuclear receptor NURR1; transcriptionally inducible nuclear receptor related 1; transcriptionally-inducible nuclear receptor
• UniProt Protein Name: Nuclear receptor subfamily 4 group A member 2
• Protein Family: Nuclear receptor subfamily
• UniProt Gene Name: NR4A2
• UniProt Entry Name: NR4A2_HUMAN

NCBI Description

This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Description

NR4A2: Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Belongs to the nuclear hormone receptor family. NR4 subfamily.

Protein type: Nuclear receptor; DNA-binding

Chromosomal Location of Human Ortholog: 2q22-q23

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: ligand-dependent nuclear receptor activity; protein binding; zinc ion binding; protein heterodimerization activity; steroid hormone receptor activity

Biological Process: positive regulation of catalytic activity; adult locomotory behavior; neuron migration; dopamine biosynthetic process; response to insecticide; signal transduction; neuron maturation; post-embryonic development; regulation of respiratory gaseous exchange; general adaptation syndrome; negative regulation of neuron apoptosis; transcription initiation from RNA polymerase II promoter; response to inorganic substance; intracellular receptor-mediated signaling pathway; transcription, DNA-dependent; death; regulation of dopamine metabolic process; response to amphetamine; central nervous system projection neuron axonogenesis; habenula development; cellular response to extracellular stimulus; response to hypoxia; steroid hormone mediated signaling; positive regulation of transcription from RNA polymerase II promoter; gene expression

Disease: Parkinson Disease, Late-onset