Rabbit anti-Human NLGN1  Monoclonal Antibody | anti-NLGN1  antibody

Rabbit anti Human NLGN1  Monoclonal Antibody

Cat. Num. AAA2544260

• Gene Names: NLGN1; NL1
• Reactivity: Human
• Applications: ELISA
• Synonyms: NLGN1 ; Monoclonal Antibody; Rabbit anti Human NLGN1 Monoclonal Antibody; anti-NLGN1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG
• Sequence Length: 823

• Applicable Applications for anti-NLGN1 antibody: ELISA (EIA)
• Application Notes: ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Human NLGN1. The detection limit for Human NLGN1 is approximately 0.0049 ng/well.
• Immunogen: Recombinant Human Neuroligin 1/NLGN1 protein
• Buffer: 0.2 mum filtered solution in PBS with 5% trehalose
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-NLGN1  antibody

Neuroligin 1 (NLGN1) belongs to the type-B carboxylesterase/lipase family, is a synaptic cell-adhesion molecule that is enriched in postsynaptic densities where it may recruit receptors, channels, and signal-transduction molecules to synaptic sites of cell adhesion. Neuroligins consist of five members (NLGN1, NLGN2, NLGN3, NLGN4 and NLGN4Y), which interact with beta-neurexins and this interaction is involved in the formation of functional synapses. The extracellular domain of functional Neuroligin 1 associates as a dimer when analyzed by sedimentation equilibrium. Neuroligin 1 has a unique N-linked glycosylation pattern in the neuroligin family, and glycosylation and its processing modify neuroligin activity. Neuroligin 1 is a potent trigger for the de novo formation of synaptic connections, and it has recently been suggested that it is required for the maturation of functionally competent excitatory synapses. The persistent expression of Neuroligin 1 is required for the maintenance of NMDAR-mediated synaptic transmission, which enables normal development of synaptic plasticity and long-term memory in the amygdala of adult animals.

NCBI and Uniprot Product Information

• NCBI GI #: 7662470
• NCBI GeneID: 22871
• NCBI GenBank Nucleotide #: NM_014932.3
• Molecular Weight: 92,000 Da
• NCBI Official Full Name: neuroligin-1
• NCBI Official Synonym Full Names: neuroligin 1
• NCBI Official Symbol: NLGN1
• NCBI Official Synonym Symbols: NL1
• NCBI Protein Information: neuroligin-1
• UniProt Protein Name: Neuroligin-1
• UniProt Gene Name: NLGN1
• UniProt Synonym Gene Names: KIAA1070
• UniProt Entry Name: NLGN1_HUMAN

NCBI Description

This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. [provided by RefSeq, Jul 2008]

Uniprot Description

NLGN1: Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Belongs to the type-B carboxylesterase/lipase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q26.31

Cellular Component: cell surface; dendrite; dendritic spine; extracellular space; filopodium tip; Golgi apparatus; integral to plasma membrane; plasma membrane; postsynaptic density; synapse

Molecular Function: cell adhesion molecule binding; neurexin binding; PDZ domain binding; protein dimerization activity; receptor activity

Biological Process: calcium-dependent cell-cell adhesion; cytoskeletal matrix organization at active zone; establishment of protein localization; heterophilic cell adhesion; nervous system development; neurite development; neuron adhesion; positive regulation of filopodium formation; positive regulation of synaptic transmission, GABAergic; positive regulation of synaptic transmission, glutamatergic; positive regulation of synaptogenesis; protein homooligomerization; protein targeting; regulation of neuron differentiation; synaptic vesicle targeting; synaptogenesis