Mouse Neuroligin-3 Monoclonal Antibody | anti-Nlgn3 antibody

Neuroligin-3 Monoclonal Antibody

Cat. Num. AAA191336

• Applications: Immunoblot, Western Blot, Immunofluorescence
• Synonyms: Neuroligin-3; Monoclonal Antibody; Neuroligin-3 Monoclonal Antibody; anti-Nlgn3 antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG1
• Specificity: This antibody recognizes human, mouse and rat Neuroligin-3. It does not crossreact with Neuroligin-1,-2, or-4.
• Form/Format: 100ug (1mg/ml) Protein G-purified antibody in PBS, pH 7.4, 0.1% sodium azide, 50% glycerol.
• Sequence Length: 848

• Applicable Applications for anti-Nlgn3 antibody: Immunoblot, Immunofluorescence (IF)
• Application Notes: Immunoblot: 1-5ug/ml. A band of ~110kDa is detected.; IF: 10ug/ml; Dilute in PBS or medium that is identical to that used in the assay system.
• Immunogen: Fusion protein corresponding to aa 730-848 (intracellular C-terminus) of rat Neuroligin3. This sequence is 99% identical to mouse and 98% identical to human Neuroligin-3.
• Preparation and Storage: This product is stable for at least one (1) year at-20 degree C.

Testing Data

(Detection of Neuroligin-3 in mouse brain lysate at 5ug/ml. )

Testing Data

(Detection of Neuroligin-3 in neuroblastoma cell line SK-N-BE at 10ug/ml: DAPI (blue) nuclear stain, Texas Red F actin stain, FITC (green) Neuroligin-3 stain.)

Related Product Information for anti-Nlgn3 antibody

Neuroligin-3 is a neuronal cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. It plays a role in synapse function and synaptic signal transmission, and may mediate its effects by clustering other synaptic proteins. It may also promote the initial formation of synapses and play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system. Mutations in this gene may be associated with autism and Asperger syndrome. Multiple transcript variants encoding distinct isoforms have been identified for this gene.

NCBI and Uniprot Product Information

• NCBI GI #: 1145791
• NCBI GeneID: 171297
• UniProt Accession #: Q62889
• Molecular Weight: 89,531 Da
• NCBI Official Full Name: neuroligin 3
• NCBI Official Synonym Full Names: neuroligin 3
• NCBI Official Symbol: Nlgn3
• NCBI Protein Information: neuroligin-3
• UniProt Protein Name: Neuroligin-3
• Protein Family: Neuroligin
• UniProt Gene Name: Nlgn3

NCBI Description

neuronal cell surface protein that binds neurexins [RGD, Feb 2006]

Uniprot Description

Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system.