Mouse Nerve Growth Factor Receptor, p75 Monoclonal Antibody | anti-NGFR antibody

Nerve Growth Factor Receptor, p75 (NGFR, NGF Receptor, CD271, Gp80 LNGFR, Low Affinity Nerve Growth Factor Receptor, Low Affinity Neurotrophin Receptor p75 NTR, p75 ICD, p75 Neurotrophin, p75 NTR, Tumor Necrosis Factor Receptor Superfamily Member 16, TNFR

Cat. Num. AAA604353

• Reactivity: Canine, Feline, Human, Porcine, Rabbit, Sheep
• Applications: ELISA, Immunohistochemistry, Flow Cytometry, Functional Assay, Immunofluorescence
• Purity: Affinity Purified; Purified by affinity chromatography.
• Synonyms: Nerve Growth Factor Receptor; p75; Monoclonal Antibody; p75 (NGFR; NGF Receptor; CD271; Gp80 LNGFR; Low Affinity Nerve Growth Factor Receptor; Low Affinity Neurotrophin Receptor p75 NTR; p75 ICD; p75 Neurotrophin; p75 NTR; Tumor Necrosis Factor Receptor Superfamily Member 16; TNFR; Anti -Nerve Growth Factor Receptor; anti-NGFR antibody

• Host: Mouse
• Reactivity: Canine, Feline, Human, Porcine, Rabbit, Sheep
• Clonality: Monoclonal
• Isotype: IgG
• Clone Number: 9G392
• Specificity: Recognizes human p75NTR (low affinity neurotrophin receptor). Species Crossreactivity: feline, canine, porcine, rabbit and sheep. Does not react with rat or mouse.
• Purity/Purification: Affinity Purified; Purified by affinity chromatography.
• Form/Format: Supplied as a lyophilized powder. Reconstitute with 100ul sterile ddH2O.

• Applicable Applications for anti-NGFR antibody: ELISA (EL/EIA), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS), Immunofluorescence (IF)
• Application Notes: Suitable for use in Immunohistochemistry, ELISA, Immunofluorescence, and Flow Cytometry. Not suitable for use in Western Blots. Does not block Neurotrophin binding.; Dilution: Immunohistochemistry: 2ug/ml; Flow Cytometry: 20ug/ml; ELISA: 1:5000; Optimal dilution determined by the researcher.
• Immunogen: Human WM245 melanoma cells.
• Preparation and Storage: Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile 40-50% glycerol, ddH2O. Reconstituted product is stable for 12 months at -20 degree C. Aliquot and store at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-NGFR antibody

Nerve growth factor receptor (NGFR) is also referred to as p75(NTR) due to its molecular mass and its ability to bind at low affinity not only NGF (see 162030), but also other neurotrophins, including brain-derived neurotrophic factor (BDNF; 113505), neurotrophin-3 (NTF3; 162660), and neurotrophin-4/5 (NTF5; 162662). At the time of its discovery, NGFR was considered a unique type of protein. Subsequently, however, a large superfamily of tumor necrosis factor receptors were found to share the overall structure of NGFR (4 extracellular ligand-binding, cysteine-rich repeats, or CRs, and signaling through association with, or disassociation from, cytoplasmic interactors). The identification of this superfamily helped elucidate some of the biologic functions of NGFR, including its ultimate involvement in the nuclear factor kappa-B (NFKB; see 164011) and apoptosis pathways. As a monomer, NGFR binds NGF with low affinity. Higher affinity binding is achieved by association with higher molecular mass, low-affinity neurotrophin receptors, namely the tropomyosin receptor kinases, TRKA (NTRK1; 191315), TRKB (NTRK2; 600456), and TRKC (NTRK3; 191316). TRKA, TRKB, and TRKC are specific for or 'preferred by' NGF, NTF5 and BDNF, and NTF3, respectively. NTF3 also binds to TRKA and TRKB, but with significantly lower affinity.

Product Categories/Family for anti-NGFR antibody

Antibodies; Abs to Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 52789066
• NCBI GeneID: 574304
• NCBI Official Full Name: nerve growth factor receptor
• NCBI Official Symbol: NGFR
• NCBI Protein Information: nerve growth factor receptor
• Protein Family: Tumor necrosis factor receptor superfamily