Mouse anti-Human Nerve Growth Factor Receptor Monoclonal Antibody | anti-NGFR antibody

Nerve Growth Factor Receptor, Human (NGFR, Neurotrophin Receptor, NTR)

Cat. Num. AAA633204

• Gene Names: NGFR; CD271; p75NTR; TNFRSF16; p75(NTR); Gp80-LNGFR
• Reactivity: Human
• Applications: Western Blot
• Purity: Affinity Purified; Purified by Protein G affinity chromatography.
• Synonyms: Nerve Growth Factor Receptor; Monoclonal Antibody; Human (NGFR; Neurotrophin Receptor; NTR); Anti -Nerve Growth Factor Receptor; anti-NGFR antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgM
• Clone Number: 1.A.31
• Specificity: Recognizes recombinant human NGF receptor.
• Purity/Purification: Affinity Purified; Purified by Protein G affinity chromatography.
• Form/Format: Supplied as a liquid in 0.1M Tris HCl, pH 7.5.

• Applicable Applications for anti-NGFR antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.; Dilution: Western Blot: 1:100
• Immunogen: Purified human recombinant NGF receptor.
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Categories/Family for anti-NGFR antibody

Antibodies; Abs to Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 189205
• NCBI GeneID: 4804
• UniProt Accession #: P08138; B2R961
• Molecular Weight: 45,183 Da
• NCBI Official Full Name: nerve growth factor receptor
• NCBI Official Synonym Full Names: nerve growth factor receptor
• NCBI Official Symbol: NGFR
• NCBI Official Synonym Symbols: CD271; p75NTR; TNFRSF16; p75(NTR); Gp80-LNGFR
• NCBI Protein Information: tumor necrosis factor receptor superfamily member 16; p75 ICD; NGF receptor; OTTHUMP00000220318; OTTHUMP00000220319; TNFR superfamily, member 16; low affinity nerve growth factor receptor; low affinity neurotrophin receptor p75NTR; low-affinity nerve growth factor receptor
• UniProt Protein Name: Tumor necrosis factor receptor superfamily member 16
• Protein Family: Tumor necrosis factor receptor superfamily
• UniProt Gene Name: NGFR
• UniProt Synonym Gene Names: TNFRSF16
• UniProt Entry Name: TNR16_HUMAN

NCBI Description

Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. [provided by RefSeq]

Uniprot Description

NGFR: Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Homodimer; disulfide-linked. Interacts with p75NTR- associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and NGFRAP1/BEX3. Interacts with KIDINS220 and NTRK1. Can form a ternary complex with NTRK1 and KIDINS220 and this complex is affected by the expression levels of KIDINS220. An increase in KIDINS220 expression leads to a decreased association of NGFR and NTRK1. Interacts with NTRK2; may regulate the ligand specificity of the NTRK2 receptor. Interacts with LINGO1.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 17q21-q22

Cellular Component: nucleoplasm; cell surface; integral to plasma membrane; plasma membrane; extracellular region; cytosol; endosome

Molecular Function: signal transducer activity; protein binding; transmembrane receptor activity; death receptor activity; ubiquitin protein ligase binding; nerve growth factor binding; receptor activity; Rab GTPase binding

Biological Process: axon guidance; detection of temperature stimulus; hair follicle morphogenesis; central nervous system development; membrane protein intracellular domain proteolysis; nerve growth factor receptor signaling pathway; negative regulation of fibroblast growth factor receptor signaling pathway; positive regulation of apoptosis; positive regulation of odontogenesis of dentine-containing teeth; regulation of caspase activity; glucose homeostasis; regulation of axonogenesis; negative regulation of hair follicle development; negative regulation of cell cycle; intracellular protein transport; positive regulation of fibroblast proliferation; nerve development; negative regulation of axonogenesis; positive regulation of axonogenesis; circadian regulation of gene expression; negative regulation of apoptosis