Mouse anti-Human, Mouse N-myc 1 Monoclonal Antibody | anti-MYCN antibody

N-myc 1 (Myc, myc-1)

Cat. Num. AAA601268

• Gene Names: MYCN; NMYC; ODED; MODED; N-myc; MYCNOT; bHLHe37
• Reactivity: Human, Mouse
• Applications: ELISA
• Purity: Purified
• Synonyms: N-myc 1; Monoclonal Antibody; N-myc 1 (Myc; myc-1); Anti -N-myc 1 (Myc; anti-MYCN antibody

• Host: Mouse
• Reactivity: Human, Mouse
• Clonality: Monoclonal
• Isotype: IgG2a
• Clone Number: 3C165
• Specificity: Specific for N-Myc. No cross-reaction with c-myc or L-myc. Species crossreactivity: Reacts with human and mouse N-myc.
• Purity/Purification: Purified
• Form/Format: Supplied as a liquid in PBS, pH 7.2.

• Applicable Applications for anti-MYCN antibody: ELISA (EL/EIA)
• Immunogen: KLH conjugated peptide to amino acids 327-339 of human N-myc. SPYVESEDAPPQKC
• Cellular Localization: Predominantly nuclear, some cytoplasmic.
• Positive Control: Neuroblastoma cell lines and tumors.
• Preparation and Storage: -20 degree C

Related Product Information for anti-MYCN antibody

Myc proteins have documented oncogenic potential and similar DNA binding properties. Studies indicate that inhibiting N-myc gene expression results in either the suppression of cell proliferation or the induction of differentiation and/or apoptosis. The oncogene v-myc was first identified as the transforming gene of the avian myelocytomatosis retrovirus MC29 (hence the name myc). Five members of the human myc family of nucleus-associated phosphoproteins (c-, N-, L-, B-, and R-myc) are currently known. The N-myc gene gives rise to at least two nuclear phosphoproteins of 64kD and 67kD with a relatively short half life (30 minutes) in vivo and exhibit DNA binding properties in vitro. Amplification of the N-myc gene has been reported in human neuroblastomas and cell lines. For example, ampli cation of the N-Myc gene is associated with a poor prognosis in some neuroblastomas. Myc proteins are potent transcriptional activators that regulate gene expression by forming heterodimers with Max and binding speci cally to CAC(G/A)TG sequence motifs in target genes. Max proteins can also form homodimers that recognize the same DNA motif as the Myc/Max heterodimer. Max homodimers, however, repress transcription. The extent of N-myc amplification correlates well with the stage of neuroblastoma disease.

Product Categories/Family for anti-MYCN antibody

Antibodies; Abs to Transcription Factors

NCBI and Uniprot Product Information

• NCBI GI #: 19923312
• NCBI GeneID: 4613
• NCBI Accession #: NP_005369.2
• NCBI GenBank Nucleotide #: NM_005378.4
• UniProt Accession #: P04198; Q6LDT9
• Molecular Weight: 49,561 Da
• NCBI Official Full Name: N-myc proto-oncogene protein
• NCBI Official Synonym Full Names: v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
• NCBI Official Symbol: MYCN
• NCBI Official Synonym Symbols: NMYC; ODED; MODED; N-myc; MYCNOT; bHLHe37
• NCBI Protein Information: N-myc proto-oncogene protein; pp65/67; oncogene NMYC; neuroblastoma MYC oncogene; class E basic helix-loop-helix protein 37; v-myc myelocytomatosis viral related oncogene, neuroblastoma derived; neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene; v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived
• UniProt Protein Name: N-myc proto-oncogene protein
• Protein Family: N-myc protein
• UniProt Gene Name: MYCN
• UniProt Synonym Gene Names: BHLHE37; NMYC; bHLHe37
• UniProt Entry Name: MYCN_HUMAN

NCBI Description

This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. [provided by RefSeq, Jul 2008]

Uniprot Description

N-Myc: a proto-oncogenic transcription factor. Plays a role in cell proliferation, apoptosis and in the development of human tumors.

Protein type: Transcription factor; DNA-binding; Oncoprotein

Chromosomal Location of Human Ortholog: 2p24.3

Cellular Component: chromatin; nucleus

Molecular Function: protein dimerization activity; protein binding; DNA binding; transcription factor activity

Biological Process: regulation of transcription from RNA polymerase II promoter; branching morphogenesis of a tube; negative regulation of astrocyte differentiation; positive regulation of mesenchymal cell proliferation; positive regulation of transcription from RNA polymerase II promoter; embryonic digit morphogenesis; embryonic skeletal morphogenesis; lung development; cartilage condensation

Disease: Feingold Syndrome 1; Tracheoesophageal Fistula With Or Without Esophageal Atresia