Testing Data
(Image: HeLa cells were stained with monoclonal antibody Muscleblind-like protein at 1: 1,000. Muscleblind-like protein 1 is present in the nucleus of HeLa cells (red). Co-staining is with our rabbit polyclonal antibody against vimentin (in red) reveals cytoplasmic intermediate filaments. Blue is a DNA stain which largely colocalizes with the MBNL1 protein in the nucleus.)
Muscleblind-like protein 1 Monoclonal Antibody
Muscleblind-like protein 1, monoclonal antibody, mouse
Reactivity
Bovine, Chicken, Human, Mouse, Porcine, Rat
Applications
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
Purity
Affinity Purified
Synonyms
Muscleblind-like protein 1; Monoclonal Antibody; monoclonal antibody; mouse; Muscleblind-like Protein; anti-Muscleblind-like protein 1 antibody
Reactivity
Bovine, Chicken, Human, Mouse, Porcine, Rat
Clonality
Monoclonal
Purity/Purification
Affinity Purified
Form/Format
Liquid
Applicable Applications for anti-Muscleblind-like protein 1 antibody
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB)
Testing Data
(Image: HeLa cells were stained with monoclonal antibody Muscleblind-like protein at 1: 1,000. Muscleblind-like protein 1 is present in the nucleus of HeLa cells (red). Co-staining is with our rabbit polyclonal antibody against vimentin (in red) reveals cytoplasmic intermediate filaments. Blue is a DNA stain which largely colocalizes with the MBNL1 protein in the nucleus.)
Testing Data
(Image: HeLa cells were stained with monoclonal antibody Muscleblind-like protein at 1: 1,000. Muscleblind-like protein 1 is present in the nucleus of HeLa cells (red). Co-staining is with our rabbit polyclonal antibody against vimentin (in red) reveals cytoplasmic intermediate filaments. Blue is a DNA stain which largely colocalizes with the MBNL1 protein in the nucleus.)
Testing Data
(Image: Western blot analysis. Blot of HL60 cell lysate was probed at dilution 1:1,000. The monoclonal binds Muscleblind-like protein 1 at ~40kDa, as expected.)
Testing Data
(Image: Western blot analysis. Blot of HL60 cell lysate was probed at dilution 1:1,000. The monoclonal binds Muscleblind-like protein 1 at ~40kDa, as expected.)
Related Product Information for anti-Muscleblind-like protein 1 antibody
Muscleblind-like Protein (MBNL1) mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. Regulates the TNNT2 exon 5 skipping through competition with U2AF2. Inhibits the formation of the spliceosome A complex on intron 4 of TNNT2 pre-mRNA. Binds to the stem-loop structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Binds to the 5-YGCU(U/G)Y-3consensus sequence. Binds to the IR RNA. Binds to expanded CUG repeat RNA, which folds into a hairpin structure containing GC base pairs and bulged, unpaired U residues.
Diseases associated with MBNL1 include myotonic dystrophy and myotonic dystrophy 1. Among its related pathways are Adipogenesis. GO annotations related to this gene include poly(A) RNA binding and double-stranded RNA binding
Diseases associated with MBNL1 include myotonic dystrophy and myotonic dystrophy 1. Among its related pathways are Adipogenesis. GO annotations related to this gene include poly(A) RNA binding and double-stranded RNA binding
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Product Notes
The Muscleblind-like protein 1 (Catalog #AAA555672) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The Muscleblind-like protein 1, monoclonal antibody, mouse reacts with Bovine, Chicken, Human, Mouse, Porcine, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Muscleblind-like protein 1 can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB). Researchers should empirically determine the suitability of the Muscleblind-like protein 1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Muscleblind-like protein 1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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