Mouse anti-Human Muellerian-Inhibiting Factor, AMH/MIS Monoclonal Antibody | anti-AMH/MIS antibody

Monoclonal Anti-Muellerian-Inhibiting Factor, AMH/MIS (Capture or Detection Ab)

Cat. Num. AAA355874

• Gene Names: AMH; MIF; MIS
• Reactivity: Human
• Applications: ELISA, Lateral Flow
• Purity: >95% by HPLC & SDS-PAGE; Protein A or G Purified
• Synonyms: Muellerian-Inhibiting Factor; AMH/MIS; Monoclonal Antibody; Monoclonal Anti-Muellerian-Inhibiting Factor; AMH/MIS (Capture or Detection Ab); anti-AMH/MIS antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: B9
• Purity/Purification: >95% by HPLC & SDS-PAGE; Protein A or G Purified
• Form/Format: Liquid; Supplied in 0.9% NaCl without preservative.
• Sequence Length: 560

• Applicable Applications for anti-AMH/MIS antibody: ELISA (EIA), Lateral Flow Assay (Rapid Test)
• Immunogen: Recombinant human AMH Protein (Expression system with 293-F cell).
• Preparation and Storage: Aliquot and store at -20 degree C for long term (at least for one year).

Related Product Information for anti-AMH/MIS antibody

Müllerian inhibiting substance/anti-Müllerian hormone (MIS/AMH) is a regulator of the female reproductive system, an indicator of ovarian reserve and a growth inhibitor of Müllerian duct-derived tumors in vivo and in vitro. It is required for sexual differentiation in the fetus, and in adult females AMH is produced by growing ovarian follicles. Consequently, AMH levels are correlated with ovarian reserve, declining towards menopause when the oocyte pool is exhausted. Ruth KS et al findings provide genetic support for the well-established use of AMH as a marker of ovarian reserve.Value of serum AMH concentration has been found not significantly superior to LH/FSH ratio in polycystic ovary syndrome, PCOS identification. Although these biomarkers separately are not adequate for PCOS identification based on their own value, the combination of different endocrine factors including AMH, LH, and LH/FSH ratio together with BMI and other anthropometric and clinical characteristics may offer extra value to establish the identification of PCOS.

Product Categories/Family for anti-AMH/MIS antibody

Matched Antibody Pairs; Small Molecule Antibodies

References

1. Ruth KS, Soares ALG, Borges MC, Eliassen AH, Hankinson SE, Jones ME, Kraft P, Nichols HB, Sandler DP, Schoemaker MJ, Taylor JA, Zeleniuch-Jacquotte A, Lawlor DA, Swerdlow AJ, Murray A. Genome-wide association study of anti-Müllerian hormone levels in pre-menopausal women of late reproductive age and relationship with genetic determinants of reproductive lifespan. Hum Mol Genet. 2019 Jan 14. 2. Le MT, Le VNS, Le DD, Nguyen VQH, Chen C, Cao NT. Exploration of the role of anti-Mullerian hormone and LH/FSH ratio in diagnosis of polycystic ovary syndrome.Clin Endocrinol (Oxf). 2019 Jan 13.

NCBI and Uniprot Product Information

• NCBI GI #: 313104218
• NCBI GeneID: 268
• UniProt Accession #: P03971
• NCBI Official Full Name: Muellerian-inhibiting factor
• NCBI Official Synonym Full Names: anti-Mullerian hormone
• NCBI Official Symbol: AMH
• NCBI Official Synonym Symbols: MIF; MIS
• NCBI Protein Information: muellerian-inhibiting factor
• UniProt Protein Name: Muellerian-inhibiting factor
• UniProt Gene Name: AMH
• UniProt Synonym Gene Names: MIF; AMH; MIS
• UniProt Entry Name: MIS_HUMAN

NCBI Description

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate N- and C-terminal cleavage products that homodimerize and associate to form a biologically active noncovalent complex. This complex binds to the anti-Mullerian hormone receptor type 2 and causes the regression of Mullerian ducts in the male embryo that would otherwise differentiate into the uterus and fallopian tubes. This protein also plays a role in Leydig cell differentiation and function and follicular development in adult females. Mutations in this gene result in persistent Mullerian duct syndrome. [provided by RefSeq, Jul 2016]

Uniprot Description

AMH: This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin. Defects in AMH are the cause of persistent Muellerian duct syndrome type 1 (PMDS1). PMDS1 is a form of male pseudohermaphroditism characterized by a failure of Muellerian duct regression in otherwise normal males. Belongs to the TGF-beta family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: extracellular space; cytoplasm; extracellular region

Molecular Function: growth factor activity; hormone activity; transforming growth factor beta receptor binding; receptor binding

Biological Process: response to drug; sex determination; Mullerian duct regression; cell-cell signaling; gonadal mesoderm development; preantral ovarian follicle growth; sex differentiation; response to organic cyclic substance; urogenital system development; activation of NF-kappaB transcription factor; aging

Disease: Persistent Mullerian Duct Syndrome, Types I And Ii