Mouse Mucin-5AC Monoclonal Antibody | anti-MUC5C antibody

Anti-Mucin Gastric Antibody (Monoclonal, 45M1)

Cat. Num. AAA175024

• Gene Names: MUC5B; MG1; MUC5; MUC9; MUC-5B
• Reactivity: Human, Mouse, Rat, Rabbit
• Applications: Western Blot, Immunohistochemistry, Immunocytochemistry
• Purity: Ascites
• Synonyms: Mucin-5AC; Monoclonal Antibody; Anti-Mucin Gastric Antibody (Monoclonal; 45M1); mucin 5AC; oligomeric mucus/gel-forming; anti-MUC5C antibody

• Host: Mouse
• Reactivity: Human, Mouse, Rat, Rabbit
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 45M1
• Purity/Purification: Ascites
• Form/Format: Lyophilized
• Sequence Length: 5762

• Applicable Applications for anti-MUC5C antibody: Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunocytochemistry (ICC)
• Application Notes: Western blot: 1-2ug/ml; Immunohistochemistry (Paraffinembedded Section): 2-4ug/ml; Immunocytochemistry: 1ug/ml
• Immunogen: Mucin from human ovarian cyst fluid.
• Contents: Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.
• Reconstitution: Add 1ml of PBS buffer will yield a concentration of 100ug/ml.
• Preparation and Storage: At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Immunohistochemistry (IHC)

(Anti- Mucin Gastric antibody, MBS175024, IHC(P)IHC(P): Human Gastric Cancer Tissue )

Immunohistochemistry (IHC)

(Anti- Mucin Gastric antibody, MBS175024, IHC(P)IHC(P): Rat Gastric Cancer Tissue )

Related Product Information for anti-MUC5C antibody

Mucin 5AC (Muc5AC) is a protein that in humans is encoded by the MUC5AC gene. Using real-time RT-PCR, Moehle et al. (2006) found that MUC5AC was highly expressed in adult trachea and stomach. Expression was lower in adult lung and weak in fetal lung, and no expression was detected in other tissues. This gene has been linked to mucus hypersecretion in the pulmonary tracts and associated to chronic obstructive pulmonary disease. Moreover, Muc5ac is identified as a direct and critical mediator of resistance during intestinal nematode infection.

NCBI and Uniprot Product Information

• NCBI GI #: 308153579
• NCBI GeneID: 727897
• UniProt Accession #: Q9HC84; O00447; O00573; O14985; O15494; O95291; O95451; Q14881; Q7M4S5; Q99552; Q9UE28
• Molecular Weight: 596,340 Da
• NCBI Official Full Name: Mucin-5B
• NCBI Official Synonym Full Names: mucin 5B, oligomeric mucus/gel-forming
• NCBI Official Symbol: MUC5B
• NCBI Official Synonym Symbols: MG1; MUC5; MUC9; MUC-5B
• NCBI Protein Information: mucin-5B; cervical mucin MUC5B; sublingual gland mucin; mucin 5, subtype B, tracheobronchial; high molecular weight salivary mucin MG1
• UniProt Protein Name: Mucin-5B
• Protein Family: Mucin
• UniProt Gene Name: MUC5B
• UniProt Synonym Gene Names: MUC5; MUC-5B
• UniProt Entry Name: MUC5B_HUMAN

NCBI Description

This gene encodes a member of the mucin family of proteins, which are highly glycosylated macromolecular components of mucus secretions. This family member is the major gel-forming mucin in mucus. It is a major contributor to the lubricating and viscoelastic properties of whole saliva, normal lung mucus and cervical mucus. This gene has been found to be up-regulated in some human diseases, including sinus mucosa of chronic rhinosinusitis (CRS), CRS with nasal polyposis, chronic obstructive pulmonary disease (COPD) and H. pylori-associated gastric disease, and it may be involved in the pathogenesis of these diseases. [provided by RefSeq, Jul 2010]

Uniprot Description

MUC5B: Gel-forming mucin that is thought to contribute to the lubricating and viscoelastic properties of whole saliva and cervical mucus. Defects in MUC5B are a cause of susceptibility to pulmonary fibrosis idiopathic (IPF). Pulmonary fibrosis is a lung disease characterized by shortness of breath, radiographically evident diffuse pulmonary infiltrates, and varying degrees of inflammation and fibrosis on biopsy. It results in acute lung injury with subsequent scarring and endstage lung disease. A common polymorphism in the promoter of MUC5B is associated with familial interstitial pneumonia and idiopathic pulmonary fibrosis, suggesting that dysregulated MUC5B expression in the lung may be involved in the pathogenesis of pulmonary fibrosis (PubMed:21506741).

Protein type: Cell adhesion; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: extracellular space; Golgi lumen

Molecular Function: protein binding

Biological Process: protein amino acid O-linked glycosylation; cellular protein metabolic process; O-glycan processing; regulation of macrophage activation; defense response to bacterium; post-translational protein modification

Disease: Pulmonary Fibrosis, Idiopathic