Mouse anti-Human MSH6 Monoclonal Antibody | anti-MSH6 antibody

MSH6 Monoclonal Antibody

Cat. Num. AAA2563567

• Gene Names: MSH6; GTBP; HSAP; p160; GTMBP; HNPCC5
• Reactivity: Human
• Applications: Immunohistochemistry, Immunohistochemistry
• Purity: Affinity purification
• Synonyms: MSH6; Monoclonal Antibody; MSH6 Monoclonal Antibody; DNA mismatch repair protein Msh6; G/T mismatch binding protein; G/T mismatch-binding protein; GTBP; GTMBP; hMSH6; HNPCC 5; HNPCC5; HSAP; MSH 6; mutS (E. coli) homolog 6; MutS alpha 160 kDa subunit; MutS homolog 6 (E. coli); mutS homolog 6; MutS-alpha 160 kDa subunit; p160; Sperm associated protein; anti-MSH6 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG
• Clone Number: LE0171
• Purity/Purification: Affinity purification
• Form/Format: PBS with 50% glycerol, 0.5% BSA and 0.02% sodium azide.
• Concentration: 1mg/mL (varies by lot)
• Sequence Length: 1360

• Applicable Applications for anti-MSH6 antibody: Immunohistochemistry (IHC) Paraffin, Immunohistochemistry (IHC)
• Application Notes: IHC: 1:100-1:200
• Immunogen: Full length protein from eukaryotic expression system.
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20?. Avoid freeze/ thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of huaman colon cancer using MSH6 Monoclonal Antibody dilution of 1:200.)

Immunohistochemistry (IHC)

(Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of huaman tonsil tissue using dilution of 1:200.)

Related Product Information for anti-MSH6 antibody

MutS protein homolog 6 (MSH6) is part of the mismatch repair (MMR) pathway which is utilized by normal proliferating cells to repair mutations that may occur during DNA replication. Antibodies to MSH6 are a useful aid for classification of tumors of the gastrointestinal tract, including associated extracolonic cancers.

Product Categories/Family for anti-MSH6 antibody

Cancer, Epigenetics and Nuclear Signaling

NCBI and Uniprot Product Information

• NCBI GI #: 4504191
• NCBI GeneID: 2956
• NCBI Accession #: NP_000170.1
• NCBI GenBank Nucleotide #: NP_000170.1
• UniProt Accession #: P52701
• NCBI Official Full Name: DNA mismatch repair protein Msh6 isoform 1
• NCBI Official Synonym Full Names: mutS homolog 6
• NCBI Official Symbol: MSH6
• NCBI Official Synonym Symbols: GTBP; HSAP; p160; GTMBP; HNPCC5
• NCBI Protein Information: DNA mismatch repair protein Msh6
• UniProt Protein Name: DNA mismatch repair protein Msh6
• Protein Family: DNA mismatch repair protein
• UniProt Gene Name: MSH6
• UniProt Synonym Gene Names: GTBP; hMSH6; GTBP; GTMBP; p160
• UniProt Entry Name: MSH6_HUMAN

NCBI Description

This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described. [provided by RefSeq, Jul 2013]