Western Blot (WB)
(Western Blot: Sample: Recombinant MCP1, Human.)
Mouse anti-Human Monocyte Chemotactic Protein 1 (MCP1) Monoclonal Antibody | anti-MCP1 antibody
Monoclonal Antibody to Monocyte Chemotactic Protein 1 (MCP1)
Immunocytochemistry in formalin fixed cells: 5-30ug/ml
Immunohistochemistry in formalin fixed frozen section: 5-30ug/ml
Immunohistochemistry in paraffin section: 5-30ug/ml
Enzyme-linked Immunosorbent Assay: 0.05-2ug/ml
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Western Blot (WB)
(Western Blot: Sample: Recombinant MCP1, Human.)
Western Blot (WB)
(Western Blot: Sample: Recombinant MCP1, Human.)
NCBI and Uniprot Product Information
NCBI Description
This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. [provided by RefSeq, Jul 2013]
Uniprot Description
CCL2: Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. Monomer or homodimer; in equilibrium. Binds to CCR2 and CCR4. Is tethered on endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans. Belongs to the intercrine beta (chemokine CC) family.
Protein type: Chemokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 17q12
Cellular Component: axon terminus; dendrite; endocytic vesicle; extracellular region; extracellular space; perikaryon; perinuclear region of cytoplasm; rough endoplasmic reticulum
Molecular Function: CCR2 chemokine receptor binding; chemokine activity; heparin binding; protein kinase activity; receptor binding
Biological Process: aging; angiogenesis; astrocyte cell migration; cell adhesion; cell surface receptor signaling pathway; cellular calcium ion homeostasis; cellular homeostasis; cellular response to insulin stimulus; chemotaxis; chronic inflammatory response; cytokine-mediated signaling pathway; cytoskeleton organization; G-protein coupled receptor signaling pathway; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; humoral immune response; inflammatory response; JAK-STAT cascade; leukocyte migration involved in inflammatory response; lipopolysaccharide-mediated signaling pathway; lymphocyte chemotaxis; macrophage chemotaxis; MAPK cascade; maternal process involved in female pregnancy; maternal process involved in parturition; monocyte chemotaxis; negative regulation of angiogenesis; negative regulation of neuron apoptosis; neutrophil chemotaxis; organ morphogenesis; organ regeneration; positive regulation of cellular extravasation; positive regulation of collagen biosynthetic process; positive regulation of endothelial cell proliferation; positive regulation of GTPase activity; positive regulation of leukocyte mediated cytotoxicity; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of synaptic transmission; positive regulation of T cell activation; positive regulation of tumor necrosis factor production; protein amino acid phosphorylation; protein kinase B signaling; regulation of cell shape; response to activity; response to amino acid; response to antibiotic; response to bacterium; response to ethanol; response to gamma radiation; response to heat; response to hypoxia; response to mechanical stimulus; response to progesterone; response to vitamin B3; response to wounding; signal transduction; transforming growth factor beta receptor signaling pathway; vascular endothelial growth factor receptor signaling pathway; viral genome replication
Disease: Human Immunodeficiency Virus Type 1, Susceptibility To; Mycobacterium Tuberculosis, Susceptibility To; Neural Tube Defects
Research Articles on MCP1
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Product Notes
The MCP1 ccl2 (Catalog #AAA2085817) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Monoclonal Antibody to Monocyte Chemotactic Protein 1 (MCP1) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Monocyte Chemotactic Protein 1 (MCP1) can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP). Western Blot: 0.5-5ug/ml Immunocytochemistry in formalin fixed cells: 5-30ug/ml Immunohistochemistry in formalin fixed frozen section: 5-30ug/ml Immunohistochemistry in paraffin section: 5-30ug/ml Enzyme-linked Immunosorbent Assay: 0.05-2ug/ml. Researchers should empirically determine the suitability of the MCP1 ccl2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Monocyte Chemotactic Protein 1 (MCP1), Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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