Mouse MFGE8 Monoclonal Antibody | anti-MFGE8 antibody

mouse anti-Human MFGE8 monoclonal Antibody

Cat. Num. AAA719395

• Gene Names: MFGE8; BA46; HMFG; MFGM; SED1; hP47; EDIL1; MFG-E8; SPAG10; OAcGD3S; HsT19888
• Reactivity: Human. Other species are not tested. Please decide the specificity by homology
• Applications: ELISA, Immunohistochemistry
• Purity: >95%, Protein G Purified
• Synonyms: MFGE8; Monoclonal Antibody; mouse anti-Human MFGE8 monoclonal Antibody; Lactadherin; Breast epithelial antigen; BA46; HMFG; MFGM Milk fat globule-EGF factor 8; anti-MFGE8 antibody

• Host: Mouse
• Reactivity: Human. Other species are not tested. Please decide the specificity by homology
• Clonality: Monoclonal
• Isotype: IgG2b
• Specificity: Specific for MFGE8 native and denatured forms
• Purity/Purification: >95%, Protein G Purified
• Sequence Length: 335

• Applicable Applications for anti-MFGE8 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Storage Buffer: Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Conjugate: Non-conjugated
• Immunogen: Recombinant Human MFGE8 protein
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-56564
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Immunohistochemistry (IHC)

(Immunohistochemical of paraffin-embedded human Colon cancer tissues using MBS719395 at dilution of 1:200)

Immunohistochemistry (IHC)

(Immunohistochemical of paraffin-embedded human breast cancer tissue using MBS719395 at dilution of 1:200)

Related Product Information for anti-MFGE8 antibody

Human MFGE8(milk fat globule-EGF factor 8;also lactadherin, breast epithelial antigen BA46, and medin) is a 46 kDa, secreted, monomeric glycoprotein that is associated with the human milk fat globule (HMFG) membrane.It is expressed by mammary epithelial cell surfaces, artery media, and in several carcinomas.Human MGFE8 is synthesized as a 387 amino acid (aa) precursor that contains a 23 aa signal sequence and a 364 aa mature region. The mature molecule contains four Nlinked glycosylation sites, an aminoterminal EGF like domain, plus C1 and C2 Iglike domains which are related to discoidin I and homologous to those of human coagulation factors V and VIII. Within the EGF like domain is an ArgGlyAsp(RGD) sequence, which is strategically placed in a hairpin loop between two antiparallel beta strands. In this way, the EGFlike domain serves as a scaffold for the RGD sequence, which is proposed to promote cell adhesion by binding cellsurface integrin receptors, such as ??v??3. Human MFGE8 shares 59%, 58%, 56%, and 52% aa sequence identity with porcine, bovine, rat, and mouse MFGE8,respectively. Functionally, MFGE8 in milk is reported to block rotavirus infection. MFGE8 expression by macrophages promotes the phagocytosis of apoptotic thymocytes by forming a bridge between phosphatidylserine on apoptotic cells, and ??v??3 integrin on phagocytes. The MFGE8 expression by macrophages controls the accumulation of apoptotic membrane fragments in atherosclerotic plaques and substantially limits lesion development.

NCBI and Uniprot Product Information

• NCBI GI #: 167830477
• NCBI GeneID: 4240
• NCBI Accession #: NP_001108086.1
• NCBI GenBank Nucleotide #: NM_001114614.2
• UniProt Accession #: Q08431; Q53FU9; Q7Z3D2; Q9BTL9; B2R6M7
• Molecular Weight: 37,523 Da
• NCBI Official Full Name: lactadherin isoform b
• NCBI Official Synonym Full Names: milk fat globule-EGF factor 8 protein
• NCBI Official Symbol: MFGE8
• NCBI Official Synonym Symbols: BA46; HMFG; MFGM; SED1; hP47; EDIL1; MFG-E8; SPAG10; OAcGD3S; HsT19888
• NCBI Protein Information: lactadherin
• UniProt Protein Name: Lactadherin
• Protein Family: Lactadherin
• UniProt Gene Name: MFGE8
• UniProt Synonym Gene Names: MFG-E8
• UniProt Entry Name: MFGM_HUMAN