Mouse Mevalonate Kinase Monoclonal Antibody | anti-MVK antibody

Mouse Anti Human Mevalonate Kinase

Cat. Num. AAA140454

• Gene Names: Mvk; Lrbp
• Applications: ELISA, Western Blot
• Purity: MVK antibody was purified by protein-A affinity chromatography.
• Synonyms: Mevalonate Kinase; Monoclonal Antibody; Mouse Anti Human Mevalonate Kinase; MVK Antibody; Mouse Anti Human; Mevalonate Kinase (Mevalonic Aciduria); LH Receptor MRNA-Binding Protein; LRBP; Mevalonate Kinase 1; MK; MVLK; EC 2.7.1.36; anti-MVK antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG3 heavy chain and Kappa light chain
• Clone Number: PAT14F6A
• Purity/Purification: MVK antibody was purified by protein-A affinity chromatography.
• Form/Format: 1mg/ml containing PBS, pH-7.4, 10% Glycerol and 0.02% Sodium Azide.; Sterile filtered colorless solution.
• Sequence Length: 395

• Applicable Applications for anti-MVK antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: The antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:500 ~ 1:5000. Recommended starting dilution is 1:1000.
• Immunogen: Anti-human MVK mAb, clone PAT14F6A, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human MVK protein 1-396 amino acids purified from E Coli.
• Preparation and Storage: For periods up to 1 month store at 4 degree C, for longer periods of time, store at -20 degree C. Prevent freeze thaw cycles.; 12 months at -20 degree C. 1 month at 4 degree C.

Related Product Information for anti-MVK antibody

Introduction: MVK is a member of the GHMP kinase family. Mevalonate is a vital mediator, and MVK an important early enzyme, in isoprenoid and sterol synthesis. MVK deficiency can result in gene mutation associated with Mevalonic aciduria, an illness which causes psychomotor retardation, failure to thrive hepatosplenomegaly, anemia and frequent febrile crises. Mutations in this gene also cause hyperimmunoglobulinaemia D and sporadic fever syndrome, in which the person suffers from recurrent episodes of fever related with lymphadenopathy, skin rash, gastrointestinal dismay and arthralgia.

Product Categories/Family for anti-MVK antibody

Monoclonal Antibodies; Anti-Human Enzymes; Monoclonal Antibodies; Anti Human Enzyme

NCBI and Uniprot Product Information

• NCBI GI #: 13592007
• NCBI GeneID: 81727
• NCBI Accession #: NP_112325.1
• NCBI GenBank Nucleotide #: NM_031063.1
• Molecular Weight: 41,988 Da
• NCBI Official Full Name: mevalonate kinase
• NCBI Official Synonym Full Names: mevalonate kinase
• NCBI Official Symbol: Mvk
• NCBI Official Synonym Symbols: Lrbp
• NCBI Protein Information: mevalonate kinase; LHR mRNA binding protein; MK
• UniProt Protein Name: Mevalonate kinase
• Protein Family: Mevalonate kinase
• UniProt Gene Name: Mvk
• UniProt Synonym Gene Names: MK
• UniProt Entry Name: KIME_RAT

NCBI Description

kinase that catalyzes the ATP-dependent phosphorylation of mevalonic acid to form mevalonate 5-phosphate; involved in the cholesterol biosynthetic pathway [RGD, Feb 2006]

Uniprot Description

MVK: May be a regulatory site in cholesterol biosynthetic pathway. Defects in MVK are the cause of mevalonic aciduria (MEVA). It is an accumulation of mevalonic acid which causes a variety of symptoms such as psychomotor retardation, dysmorphic features, cataracts, hepatosplenomegaly, lymphadenopathy, anemia, hypotonia, myopathy, and ataxia. Defects in MVK are the cause of hyperimmunoglobulinemia D and periodic fever syndrome (HIDS). HIDS is an autosomal recessive disease characterized by recurrent episodes of unexplained high fever associated with skin rash, diarrhea, adenopathy (swollen, tender lymph nodes), athralgias and/or arthritis. Concentration of IgD, and often IgA, are above normal. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.

Protein type: Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; Kinase, other; RNA-binding; Translation; EC 2.7.1.36