Mouse anti-Human Methionine Adenosyltransferase II Alpha Monoclonal Antibody | anti-MAT2A antibody
Mouse Anti Human Methionine Adenosyltransferase II Alpha
Gene Names
MAT2A; MATA2; MATII; SAMS2
Reactivity
Human
Applications
ELISA, Western Blot, Immunohistochemistry
Purity
MAT2A antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Synonyms
Methionine Adenosyltransferase II Alpha; Monoclonal Antibody; Mouse Anti Human Methionine Adenosyltransferase II Alpha; MAT2A Antibody; Mouse Anti Human; MATA2; MATII; SAMS2; MAT-2A; S-adenosylmethionine synthetase isoform type-2; AdoMet synthetase 2; Methionine adenosyltransferase 2; Methionine adenosyltransferase II; MAT2A; AMS2; anti-MAT2A antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG2b heavy chain and kappa light chain
Clone Number
PAT3A2AT
Purity/Purification
MAT2A antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Form/Format
Sterile filtered colorless solution.
Concentration
1mg/ml containing PBS, pH-7.4, & 0.02% Sodium Azide and 10% glycerol. (varies by lot)
Sequence Length
395
Applicable Applications for anti-MAT2A antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes
MAT2A antibody has been tested by ELISA, Western blot and immunohistochemistry analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.
Immunogen
Anti-human MAT2A mAb is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human MAT2A amino acids 1-395 purified from E. coli.
Preparation and Storage
Short Term: 4°C
Long Term: -20°C
Long Term: -20°C
Related Product Information for anti-MAT2A antibody
Introduction: MAT2A is an important enzyme in cellular metabolism and catalyzes the formation of S-adenosylmethionine (SAMe) from L-methionine and ATP. MAT2A is expressed in extrahepatic tissues. In liver, MAT2A expression associates with growth, dedifferentiation, and cancer. NF-kappa B and AP-1 are necessary for basal MAT2A expression in HepG2 cells and mediate the increase in MAT2A expression in response to TNF-alpha. Up-regulation of MAT2A provides growth improvement and s-adenosylmethionine and methylthioadenosine thus can block mitogenic signaling in colon cancer cells. Lower expression of both MAT2A and MAT2beta and interfere with leptin signaling in liver cancer cells.
Product Categories/Family for anti-MAT2A antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
32,965 Da
NCBI Official Full Name
S-adenosylmethionine synthase isoform type-2
NCBI Official Synonym Full Names
methionine adenosyltransferase II, alpha
NCBI Official Symbol
MAT2A
NCBI Official Synonym Symbols
MATA2; MATII; SAMS2
NCBI Protein Information
S-adenosylmethionine synthase isoform type-2; MAT 2; MAT-II; adoMet synthase 2; adoMet synthetase 2; methionine adenosyltransferase 2
UniProt Protein Name
S-adenosylmethionine synthase isoform type-2
Protein Family
UniProt Gene Name
MAT2A
UniProt Synonym Gene Names
AMS2; MATA2; AdoMet synthase 2; MAT 2; MAT-II
UniProt Entry Name
METK2_HUMAN
NCBI Description
The protein encoded by this gene catalyzes the production of S-adenosylmethionine (AdoMet) from methionine and ATP. AdoMet is the key methyl donor in cellular processes. [provided by RefSeq, Jun 2011]
Uniprot Description
MAT2A: Catalyzes the formation of S-adenosylmethionine from methionine and ATP. Belongs to the AdoMet synthase family.
Protein type: Transferase; EC 2.5.1.6; Other Amino Acids Metabolism - selenoamino acid; Amino Acid Metabolism - cysteine and methionine
Chromosomal Location of Human Ortholog: 2p11.2
Cellular Component: methionine adenosyltransferase complex; cytosol
Molecular Function: protein binding; methionine adenosyltransferase activity; metal ion binding; ATP binding
Biological Process: methylation; xenobiotic metabolic process; S-adenosylmethionine biosynthetic process; one-carbon compound metabolic process
Research Articles on MAT2A
Similar Products
Product Notes
The MAT2A mat2a (Catalog #AAA140284) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Mouse Anti Human Methionine Adenosyltransferase II Alpha reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Methionine Adenosyltransferase II Alpha can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC). MAT2A antibody has been tested by ELISA, Western blot and immunohistochemistry analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Researchers should empirically determine the suitability of the MAT2A mat2a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Methionine Adenosyltransferase II Alpha, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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