Mouse anti-Human, Rat MBP Monoclonal Antibody | anti-MBP antibody

MOUSE ANTI BOVINE MBP (aa129-138)

Cat. Num. AAA214185

• Reactivity: Human, Rat
• Applications: Immunohistochemistry, ELISA
• Synonyms: MBP; Monoclonal Antibody; MOUSE ANTI BOVINE MBP (aa129-138); anti-MBP antibody

• Host: Mouse
• Reactivity: Human, Rat
• Clonality: Monoclonal
• Isotype: IgG2a
• Clone Number: 1
• Form/Format: Tissue Culture Supernatant - liquid
• Sequence Length: 169

• Applicable Applications for anti-MBP antibody: Immunohistology Frozen, ELISA (EIA)
• Application Notes: Immunohistology - Frozen: Maximum Dilution: 1/10;; ELISA: Minimum Dilution: 1/200; Maximum Dilution: 1/1000
• Perservative Stabilisers: 0.1% Sodium Azide; Preparation
• Target Species: Bovine
• Preparation and Storage: Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.; Shelf Life: 18 months from date of despatch.

Related Product Information for anti-MBP antibody

Mouse anti Bovine MBP (aa129-138) antibody, clone 1 recognizes myelin basic protein (MBP). Clone 1 is reactive with an epitope in the 129-138 region of the human MBP molecule. The numbering of MBP residues is that as described by Martenson Martenson, R. E., 1984. Clone 1 (129-138) has been reported as being suitable for Western blotting.

NCBI and Uniprot Product Information

• NCBI GI #: 126796
• NCBI GeneID: 618684
• UniProt Accession #: P02687; Q9BGM8; Q9TS63; Q9TSA6
• Molecular Weight: 18,323 Da
• NCBI Official Full Name: Myelin basic protein
• NCBI Official Synonym Full Names: myelin basic protein
• NCBI Official Symbol: MBP
• NCBI Protein Information: myelin basic protein; 20 kDa microtubule-stabilizing protein; myelin A1 protein
• UniProt Protein Name: Myelin basic protein
• Protein Family: Myelin basic protein
• UniProt Gene Name: MBP
• UniProt Synonym Gene Names: MBP
• UniProt Entry Name: MBP_BOVIN

Uniprot Description

MBP: The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non- classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T- cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. Homodimer. Isoform 3 exists as a homodimer. MBP isoforms are found in both the central and the peripheral nervous system, whereas Golli-MBP isoforms are expressed in fetal thymus, spleen and spinal cord, as well as in cell lines derived from the immune system. Belongs to the myelin basic protein family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal

Cellular Component: plasma membrane; myelin sheath

Molecular Function: protein binding; structural constituent of myelin sheath