Mouse MAP2 / MAP-2 Monoclonal Antibody | anti-MAP2 antibody

Mouse Monoclonal [clone MT-08] (IgG1) to Bovine MAP2 / MAP-2

Cat. Num. AAA245123

• Gene Names: MAP2; MAP2A; MAP2B; MAP2C
• Reactivity: Bovine, Human, Mouse, Pig
• Applications: Immunohistochemistry, Immunocytochemistry, Western Blot, Immunoprecipitation, ELISA
• Purity: Protein A Purified
• Synonyms: MAP2 / MAP-2; Monoclonal Antibody; Mouse Monoclonal [clone MT-08] (IgG1) to Bovine MAP2 / MAP-2; Anti-MAP2 / MAP-2 Antibody (clone MT-08) IHC-plus; MAP2; MAP2C; MAP-2; MAP2A; MAP2B; Bovine MAP2; anti-MAP2 antibody

• Host: Mouse
• Reactivity: Bovine, Human, Mouse, Pig
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: MT-08
• Specificity: Microtubule protein (bovine brain) enriched for kinesin
• Purity/Purification: Protein A Purified
• Form/Format: PBS, 15 mM sodium azide, approx., pH 7.4. Sourced in TCS.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 1827

• Applicable Applications for anti-MAP2 antibody: Immunohistochemistry (IHC - Paraffin; IHC - Frozen), Immunocytochemistry (ICC), Western Blot (WB), Immunoprecipitation (IP), ELISA (EIA)
• Application Notes: ELISA, ICC, IHC-Fr, IHC-P (10 ug/ml), IP, WB; Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
• Target Species: Bovine
• Immunogen Description: Protein fraction.
• Immunogen: MAP2 / MAP-2 antibody was raised against protein fraction.
• Preparation and Storage: Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.

Immunohistochemistry (IHC)

(Anti-MAP2 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.)

NCBI and Uniprot Product Information

• NCBI GI #: 87578396
• NCBI GeneID: 4133
• NCBI Accession #: NP_002365.3
• NCBI GenBank Nucleotide #: NM_002374.3
• UniProt Accession #: P11137; Q17S04; Q8IUX2; Q99975; Q99976
• Molecular Weight: 58,954 Da
• NCBI Official Full Name: microtubule-associated protein 2 isoform 1
• NCBI Official Synonym Full Names: microtubule-associated protein 2
• NCBI Official Symbol: MAP2
• NCBI Official Synonym Symbols: MAP2A; MAP2B; MAP2C
• NCBI Protein Information: microtubule-associated protein 2; MAP-2
• UniProt Protein Name: Microtubule-associated protein 2
• Protein Family: Microtubule-associated protein
• UniProt Gene Name: MAP2
• UniProt Synonym Gene Names: MAP-2
• UniProt Entry Name: MTAP2_HUMAN

NCBI Description

This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2010]

Uniprot Description

MAP2: a member of the microtubule-associated protein (MAP) family. Its exact function is unknown but MAPs appear to stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. Expressed at high levels in neural tissue and the prostate. Four alternatively spliced transcript variants have been reported.

Protein type: Motility/polarity/chemotaxis; Cytoskeletal

Chromosomal Location of Human Ortholog: 2q34-q35

Cellular Component: microtubule; microtubule associated complex; cell soma; cytoplasm; nucleolus; dendritic shaft

Molecular Function: calmodulin binding; protein binding; microtubule binding; structural molecule activity

Biological Process: axonogenesis; dendrite morphogenesis; microtubule bundle formation; neurite development; central nervous system neuron development