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Mouse anti-Human Macrophage inflammatory protein 2-alpha Monoclonal Antibody | anti-CXCL2 antibody

Macrophage inflammatory protein 2-alpha (CXCL2, Chemokine (C-X-C motif) ligand 2, CINC-2a, GRO2, GROb, GROB, Gro-beta, Growth-regulated protein beta, Macrophage inflammatory protein 2-alpha precursor, MGSA-b, MGSA beta, MIP2, MIP2A, MIP-2a, MIP2-alpha, SC

Gene Names
CXCL2; GRO2; GROb; MIP2; MIP2A; SCYB2; MGSA-b; MIP-2a; CINC-2a
Reactivity
Human
Applications
ELISA, Western Blot
Purity
Affinity Purified
Purified by Protein G affinity chromatography.
Synonyms
Macrophage inflammatory protein 2-alpha; Monoclonal Antibody; Macrophage inflammatory protein 2-alpha (CXCL2; Chemokine (C-X-C motif) ligand 2; CINC-2a; GRO2; GROb; GROB; Gro-beta; Growth-regulated protein beta; Macrophage inflammatory protein 2-alpha precursor; MGSA-b; MGSA beta; MIP2; MIP2A; MIP-2a; MIP2-alpha; SC; Anti -Macrophage inflammatory protein 2-alpha (CXCL2; anti-CXCL2 antibody
Ordering
For Research Use Only!
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG2b
Clone Number
1.A.12
Specificity
Recognizes recombinant human MIP2 alpha. Crossreacts with recombinant human-MIP2b and recombinant human-MIP-2a (ELISA). Does not crossreact with recombinant human-MIP1a or recombinant human-MIP1b.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Form/Format
Supplied as a liquid in 0.1M Tris HCl, pH 7.5.
Applicable Applications for anti-CXCL2 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes
Suitable for use in ELISA and Western Blot.
Dilution: Western Blot: 10ug/ml
Immunogen
Recombinant human MIP-2a produced in genetically engineered yeast and purified by sequential chromatography.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Related Product Information for anti-CXCL2 antibody
Chemokine (C-X-C motif) ligand 2 (CXCL2) is a small cytokine belonging to the CXC chemokine family that is also called macrophage inflammatory protein 2-alpha (MIP2-alpha), Growth-regulated protein beta (Gro-beta) and Gro oncogene-2 (Gro-2). CXCL2 is 90% identical in amino acid sequence as a related chemokine, CXCL1. This chemokine is secreted by monocytes and macrophages and is chemotactic for polymorphonuclear leukocytes and hematopoietic stem cells. The gene for CXCL2 is located on human chromosome 4 in a cluster of other CXC chemokines.[CXCL2 mobilizes cells by interacting with a cell surface chemokine receptor called CXCR2.
Product Categories/Family for anti-CXCL2 antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
11,389 Da
NCBI Official Full Name
macrophage inflammatory protein 2 alpha
NCBI Official Synonym Full Names
chemokine (C-X-C motif) ligand 2
NCBI Official Symbol
CXCL2
NCBI Official Synonym Symbols
GRO2; GROb; MIP2; MIP2A; SCYB2; MGSA-b; MIP-2a; CINC-2a
NCBI Protein Information
C-X-C motif chemokine 2; gro-beta; MGSA beta; MIP2-alpha; GRO2 oncogene; OTTHUMP00000219185; growth-regulated protein beta; macrophage inflammatory protein 2-alpha; melanoma growth stimulatory activity beta
UniProt Protein Name
C-X-C motif chemokine 2
Protein Family
UniProt Gene Name
CXCL2
UniProt Synonym Gene Names
GRO2; GROB; MIP2A; SCYB2
UniProt Entry Name
CXCL2_HUMAN

NCBI Description

This antimicrobial gene is part of a chemokine superfamily that encodes secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CXC subfamily, is expressed at sites of inflammation and may suppress hematopoietic progenitor cell proliferation. [provided by RefSeq, Sep 2014]

Uniprot Description

CXCL2: Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: extracellular space; extracellular region

Molecular Function: protein binding; chemokine activity; CXCR chemokine receptor binding

Biological Process: G-protein coupled receptor protein signaling pathway; response to molecule of bacterial origin; immune response; positive regulation of leukocyte chemotaxis; response to lipopolysaccharide; inflammatory response; chemotaxis; regulation of cell proliferation

Research Articles on CXCL2

Similar Products

Product Notes

The CXCL2 cxcl2 (Catalog #AAA607542) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Macrophage inflammatory protein 2-alpha (CXCL2, Chemokine (C-X-C motif) ligand 2, CINC-2a, GRO2, GROb, GROB, Gro-beta, Growth-regulated protein beta, Macrophage inflammatory protein 2-alpha precursor, MGSA-b, MGSA beta, MIP2, MIP2A, MIP-2a, MIP2-alpha, SC reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Macrophage inflammatory protein 2-alpha can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Suitable for use in ELISA and Western Blot. Dilution: Western Blot: 10ug/ml. Researchers should empirically determine the suitability of the CXCL2 cxcl2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Macrophage inflammatory protein 2-alpha, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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