Mouse anti-Human LGR5/GPR49 Monoclonal Antibody | anti-LGR5/GPR49 antibody

LGR5/GPR49 (LGR5, GPR49, GPR67, Leucine-rich repeat-containing G-protein coupled receptor 5, G-protein coupled receptor 49, G-protein coupled receptor 67, G-protein coupled receptor HG38) (MaxLight 750)

Cat. Num. AAA6257794

• Gene Names: LGR5; FEX; HG38; GPR49; GPR67; GRP49
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Ammonium Sulfate Precipitation
• Synonyms: LGR5/GPR49; Monoclonal Antibody; LGR5/GPR49 (LGR5; GPR49; GPR67; Leucine-rich repeat-containing G-protein coupled receptor 5; G-protein coupled receptor 49; G-protein coupled receptor 67; G-protein coupled receptor HG38) (MaxLight 750); LGR5; G-protein coupled receptor HG38; anti-LGR5/GPR49 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 349CT16.1.3.1
• Purity/Purification: Purified by Ammonium Sulfate Precipitation
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight750.

• Applicable Applications for anti-LGR5/GPR49 antibody: FLISA, Western Blot (WB)
• Immunogen: Purified His-tagged LGR5/GPR49 protein (fragment).
• Conjugate: MaxLight750
• Preparation and Storage: Store at 4 degree C. Do Not Freeze.

Western Blot (WB)

(LGR5/GPR49 Antibody western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the LGR5/GPR49 antibody detected the LGR5/GPR49 protein (arrow).)

Product Categories/Family for anti-LGR5/GPR49 antibody

Antibodies; G Protein Receptors

References

Fontaine-Bisson, B., et al. Diabetologia 53(10):2155-2162(2010) Voight, B.F., et al. Nat. Genet. 42(7):579-589(2010) Uchida, H., et al. Cancer Sci. 101(7):1731-1737(2010) Fan, X.S., et al. Int J Colorectal Dis 25(5):583-590(2010) Acevedo, A.C., et al. J. Dent. Res. 89(2):128-132(2010)

NCBI and Uniprot Product Information

• NCBI GI #: 4504379
• NCBI GeneID: 8549
• NCBI Accession #: NP_003658.1
• NCBI GenBank Nucleotide #: NM_003667.3
• UniProt Accession #: O75473; Q4VAM0; Q4VAM2; Q9UP75; D8MCT0
• Molecular Weight: 92,006 Da
• NCBI Official Full Name: leucine-rich repeat-containing G-protein coupled receptor 5 isoform 1
• NCBI Official Synonym Full Names: leucine-rich repeat containing G protein-coupled receptor 5
• NCBI Official Symbol: LGR5
• NCBI Official Synonym Symbols: FEX; HG38; GPR49; GPR67; GRP49
• NCBI Protein Information: leucine-rich repeat-containing G-protein coupled receptor 5; G-protein coupled receptor 49; G-protein coupled receptor 67; G-protein coupled receptor HG38; orphan G protein-coupled receptor HG38; leucine-rich repeat-containing G protein-coupled receptor 5
• UniProt Protein Name: Leucine-rich repeat-containing G-protein coupled receptor 5
• UniProt Gene Name: LGR5
• UniProt Synonym Gene Names: GPR49; GPR67

NCBI Description

The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

Uniprot Description

Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development.