Western Blot (WB)
(Western Blot analysis of HeLa cells using LDLR Monoclonal Antibody at dilution of 1:4000)
Mouse anti-Human LDLR Monoclonal Antibody | anti-LDLR antibody
LDLR Monoclonal Antibody
IHC: 1:50-1:500
Western Blot (WB)
(Western Blot analysis of HeLa cells using LDLR Monoclonal Antibody at dilution of 1:4000)
Western Blot (WB)
(Western Blot analysis of HeLa cells using LDLR Monoclonal Antibody at dilution of 1:4000)
NCBI and Uniprot Product Information
Observed Molecular Weight: 120kDa; 160kDa
NCBI Description
The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]
Uniprot Description
LDLR: Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. In case of HIV-1 infection, functions as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells. Defects in LDLR are the cause of familial hypercholesterolemia (FH); a common autosomal semi- dominant disease that affects about 1 in 500 individuals. The receptor defect impairs the catabolism of LDL, and the resultant elevation in plasma LDL-cholesterol promotes deposition of cholesterol in the skin (xanthelasma), tendons (xanthomas), and coronary arteries (atherosclerosis). Belongs to the LDLR family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell surface; Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 19p13.2
Cellular Component: apical part of cell; basolateral plasma membrane; cell surface; clathrin-coated pit; early endosome; endosome membrane; external side of plasma membrane; Golgi apparatus; integral component of plasma membrane; intracellular; late endosome; low-density lipoprotein particle; lysosome; membrane; PCSK9-LDLR complex; plasma membrane; receptor complex; somatodendritic compartment
Molecular Function: amyloid-beta binding; calcium ion binding; clathrin heavy chain binding; identical protein binding; low-density lipoprotein particle binding; low-density lipoprotein receptor activity; protease binding; protein binding; very-low-density lipoprotein receptor activity; viral receptor activity
Biological Process: cellular response to fatty acid; cellular response to low-density lipoprotein particle stimulus; cholesterol homeostasis; cholesterol metabolic process; cholesterol transport; chylomicron remnant clearance; endocytosis; entry of virus into host cell; intestinal cholesterol absorption; lipid metabolic process; lipoprotein catabolic process; long-term memory; low-density lipoprotein particle clearance; negative regulation of amyloid fibril formation; negative regulation of astrocyte activation; negative regulation of gene expression; negative regulation of microglial cell activation; negative regulation of protein metabolic process; phospholipid transport; plasma lipoprotein particle clearance; positive regulation of amyloid-beta clearance; positive regulation of endocytosis; positive regulation of gene expression; positive regulation of inflammatory response; positive regulation of lipoprotein particle clearance; positive regulation of lysosomal protein catabolic process; positive regulation of triglyceride biosynthetic process; receptor-mediated endocytosis; receptor-mediated endocytosis involved in cholesterol transport; regulation of cholesterol homeostasis; regulation of cholesterol metabolic process; regulation of phosphatidylcholine catabolic process; regulation of protein metabolic process; response to caloric restriction
Disease: Hypercholesterolemia, Familial
Research Articles on LDLR
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Product Notes
The LDLR ldlr (Catalog #AAA2549093) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The LDLR Monoclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's LDLR can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA). WB: 1:1000-1:10000 IHC: 1:50-1:500. Researchers should empirically determine the suitability of the LDLR ldlr for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "LDLR, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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