Mouse anti-Human KIR2DL3 Monoclonal Antibody | anti-KIR2DL3 antibody
KIR2DL3 (p58 KIR, CD158, cl-6, KIR-K7, NKAT2, NKR-K7, Killer Cell Immunoglobulin (Ig)-like Receptor)
Purified from mouse ascitic fluid by Protein G affinity chromatography. 95% (SDS-PAGE).
Purified from mouse ascitic fluid by Protein G affinity chromatography. 95% (SDS-PAGE).
Dilution: Flow Cytometry: 5-10ug/1x10e6
ELISA: 1:500 when tested against the immunizing protein
Western Blot: 1ug/ml
NCBI and Uniprot Product Information
NCBI Description
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq]
Uniprot Description
KIR2DL3: Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis. Belongs to the immunoglobulin superfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Receptor, misc.
Chromosomal Location of Human Ortholog: 19q13.4
Cellular Component: integral to plasma membrane; integral to membrane; plasma membrane
Molecular Function: protein binding; receptor activity; antigen binding
Biological Process: regulation of immune response; immune response
Research Articles on KIR2DL3
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Product Notes
The KIR2DL3 kir2dl3 (Catalog #AAA633243) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The KIR2DL3 (p58 KIR, CD158, cl-6, KIR-K7, NKAT2, NKR-K7, Killer Cell Immunoglobulin (Ig)-like Receptor) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's KIR2DL3 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB), Flow Cytometry (FC/FACS). Suitable for use in Flow Cytometry, ELISA and Western Blot. Dilution: Flow Cytometry: 5-10ug/1x10e6 ELISA: 1:500 when tested against the immunizing protein Western Blot: 1ug/ml. Researchers should empirically determine the suitability of the KIR2DL3 kir2dl3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "KIR2DL3, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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