Testing Data
(Staining of human peripheral blood lymphocytes with K1853.)
Mouse anti-Human Kir Monoclonal Antibody
Kir (KIR2D, Killer Cell Immunoglobulin (Ig)-like Receptor, CD158a, CD158b, P50.3) (APC)
Reactivity
Human
Applications
ELISA, Immunoprecipitation, Western Blot
Purity
Purified by Protein G Affinity Chromatography
Synonyms
Kir; Monoclonal Antibody; Kir (KIR2D; Killer Cell Immunoglobulin (Ig)-like Receptor; CD158a; CD158b; P50.3) (APC); anti-Kir antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG1
Clone Number
4j52
Specificity
Recognizes human killer cell immunoglobulin (Ig)-like receptor, CD158a, CD158b and P50.3. Recognizes the long and short forms CD158a and CD158b (KIR2DL, KIR2DS1 and KIR2DS2 respectively) and also p50.3 (KIR2DS4). Reported to have functional activity, activating NK cell cytotoxicity via KIR2DS and inhibiting via KIR2DL forms.
Purity/Purification
Purified by Protein G Affinity Chromatography
Form/Format
Supplied as a liquid in PBS, pH 7.2. Labeled with Allophycocyanin (APC).
Applicable Applications for anti-Kir antibody
ELISA (EIA), Immunoprecipitation (IP), Western Blot (WB)
Immunogen
Human natural killer (NK) cell lysate
Conjugate
APC
Preparation and Storage
Store at 4 degree C. Do Not Freeze.
Testing Data
(Staining of human peripheral blood lymphocytes with K1853.)
Testing Data
(Staining of human peripheral blood lymphocytes with K1853.)
Product Categories/Family for anti-Kir antibody
References
1. Spaggiari, G. M. et al. (2002) Soluble HLA class I molecules induce natural killer cell apoptosis through the engagement of CD8: evidence for a negative regulation exerted by members of the inhibitory receptor superfamily. Blood. 99: 1706 - 1714. 2. Spaggiari, G. M. et al. (2002) Soluble HLA class I induces NK cell apoptosis upon the engagement of killer-activating HLA class I receptors through FasL-Fas interaction. Blood: 100: 4098 - 4107. 3. Older Aguilar, A.M. et al. (2010) Coevolution of Killer Cell Ig-Like Receptors with HLA-C To Become the Major Variable Regulators of Human NK Cells. J Immunol. 185: 4238-51.
Similar Products
Product Notes
The Kir (Catalog #AAA6268937) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Kir (KIR2D, Killer Cell Immunoglobulin (Ig)-like Receptor, CD158a, CD158b, P50.3) (APC) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Kir can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunoprecipitation (IP), Western Blot (WB). Researchers should empirically determine the suitability of the Kir for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Kir, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
